Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-, 6-, and 7-positions.
Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the n class="Chemical">oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-, 6-, and 7-positions.
Authors: Michael P Hay; Kevin O Hicks; Karin Pchalek; Ho H Lee; Adrian Blaser; Frederik B Pruijn; Robert F Anderson; Sujata S Shinde; William R Wilson; William A Denny Journal: J Med Chem Date: 2008-10-11 Impact factor: 7.446
Authors: Amy E Thompson; Gregory Hughes; Andrei S Batsanov; Martin R Bryce; Paul R Parry; Brian Tarbit Journal: J Org Chem Date: 2005-01-07 Impact factor: 4.354
Authors: Michael P Hay; Karin Pchalek; Frederik B Pruijn; Kevin O Hicks; Bronwyn G Siim; Robert F Anderson; Sujata S Shinde; Victoria Phillips; William A Denny; William R Wilson Journal: J Med Chem Date: 2007-12-06 Impact factor: 7.446