| Literature DB >> 28439012 |
James A Rogers1, Manoj K Mishra1, Jennifer Hahn1, Catherine J Greene2, Robin M Yates2,3, Luanne M Metz1, V Wee Yong4.
Abstract
Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with endocrine-disrupting capabilities, altered susceptibility in an inflammatory model of multiple sclerosis. We found that gestational, but not adult, exposure to bisphenol-A increased the development of experimental autoimmune encephalomyelitis in adulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used. Gestational bisphenol-A in male mice primed macrophages in adulthood and raised granulocyte-colony stimulating factor and neutrophil counts/activity postsuboptimal immunization. Neutralizing granulocyte-colony stimulating factor blocked susceptibility to disease in bisphenol-A mice. Early life exposure to bisphenol-A may represent an environmental consideration in multiple sclerosis.Entities:
Keywords: bisphenol A; experimental autoimmune encephalomyelitis; gestational exposure; innate immunity; multiple sclerosis
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Year: 2017 PMID： 28439012 PMCID： PMC5441731 DOI： 10.1073/pnas.1620774114
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205