Literature DB >> 28438926

Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models.

Luisa Christensen1,2, Rob Turner3, Sean Weaver3, Francesco Caserta3, Lisa Long1,2, Mahmoud Ghannoum4,2, Marc Brown3,5.   

Abstract

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  miconazole; onychomycosis; topical

Mesh：

Substances：

Year:  2017        PMID： 28438926      PMCID： PMC5487659          DOI： 10.1128/AAC.02554-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents.

Authors:  M J Traynor; R B Turner; C R G Evans; R H Khengar; S A Jones; M B Brown
Journal:  J Pharm Pharmacol       Date:  2010-06       Impact factor: 3.765

2.  Topical treatments for onychomycosis: a historical perspective.

Authors:  Myron A Bodman; Lisa Feder; Angela M Nace
Journal:  J Am Podiatr Med Assoc       Date:  2003 Mar-Apr

3.  Ability of hydroxypropyl chitosan nail lacquer to protect against dermatophyte nail infection.

Authors:  M A Ghannoum; L Long; N Isham; A Bulgheroni; M Setaro; M Caserini; R Palmieri; F Mailland
Journal:  Antimicrob Agents Chemother       Date:  2014-12-29       Impact factor: 5.191

4.  Overcoming the nail barrier: A systematic investigation of ungual chemical penetration enhancement.

Authors:  M B Brown; R H Khengar; R B Turner; B Forbes; M J Traynor; C R G Evans; S A Jones
Journal:  Int J Pharm       Date:  2008-11-24       Impact factor: 5.875

5.  Update on the management of onychomycosis: highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy.

Authors:  B E Elewski; R J Hay
Journal:  Clin Infect Dis       Date:  1996-08       Impact factor: 9.079

6.  Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers.

Authors:  R H Khengar; S A Jones; R B Turner; B Forbes; M B Brown
Journal:  Pharm Res       Date:  2007-07-31       Impact factor: 4.200
  6 in total
  1 in total

1.  Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.

Authors:  Derry K Mercer; Colin S Stewart; Lorna Miller; Jennifer Robertson; Vanessa M S Duncan; Deborah A O'Neil
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191
  1 in total

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