Kenji Nakamura1, Mifuji Tomioku2, Kazuhito Nabeshima2, Eiji Nomura3. 1. Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Japan nakaken@is.icc.u-tokai.ac.jp. 2. Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Japan. 3. Department of Gastroenterological and General Surgery, Tokai University Hachioji Hospital, Hachioji, Japan.
Abstract
BACKGROUND: The aim of this study was to clarify the impact of the horizontal width of tumor invasion into the subserosal layer on prognosis in patients with T3N0 gastric cancer. PATIENTS AND METHODS: A total of 72 patients with T3N0 cancer were enrolled. Relapse-free survival of the subgroups classified according to width of subserosal invasion was compared to that of 34 patients with T4aN0 cancer. RESULTS: The group with wide invasion (≥1.5 cm) had a significantly poorer prognosis than those with narrow invasion (<1.5 cm) (p=0.014). Multivariate analysis revealed the width of subserosal invasion to be an independent prognostic factor. There was no significant difference between the T3N0 group with wide invasion and the T4aN0 group in the prognosis and recurrent status. CONCLUSION: The malignant potential of T3N0 gastric cancer with wide subserosal invasion was found to be similar to that of T4aN0 cancer. Copyright
BACKGROUND: The aim of this study was to clarify the impact of the horizontal width of tumor invasion into the subserosal layer on prognosis in patients with T3N0 gastric cancer. PATIENTS AND METHODS: A total of 72 patients with T3N0 cancer were enrolled. Relapse-free survival of the subgroups classified according to width of subserosal invasion was compared to that of 34 patients with T4aN0 cancer. RESULTS: The group with wide invasion (≥1.5 cm) had a significantly poorer prognosis than those with narrow invasion (<1.5 cm) (p=0.014). Multivariate analysis revealed the width of subserosal invasion to be an independent prognostic factor. There was no significant difference between the T3N0 group with wide invasion and the T4aN0 group in the prognosis and recurrent status. CONCLUSION: The malignant potential of T3N0 gastric cancer with wide subserosal invasion was found to be similar to that of T4aN0 cancer. Copyright
Authors: Changhoon Yoo; Min-Hee Ryu; Young Soo Park; Moon-Won Yoo; Sook Ryun Park; Baek-Yeol Ryoo; Se Jin Jang; Jeong Hwan Yook; Byung Sik Kim; Yoon-Koo Kang Journal: Ann Surg Oncol Date: 2015-01-21 Impact factor: 5.344