| Literature DB >> 28438315 |
Xiaoyan Xu1, Jian Zhang1, Shaowei Zhan2, Zhidan Li1, Xianbing Liu1, Haixia Zhang1, Yuzhu Jiang1, Xuemei Hu3.
Abstract
Our current aim was to investigate whether injection of TGF-β1 played an important role in improving abnormal pregnancy outcomes with T. gondii infection and how the TGF-β1 regulated. Results showed that TGF-β1 exhibited improved pregnancy outcomes induced by T. gondii infection. dNK cytotoxicity was increased with T. gondii infection while decreased with TGF-β1 treatment. dNK cytotoxicity related NKG2D/DAP10 expression, perforin, granzyme, IFN-γ and killer subsets were all increased with T. gondii infection while decreased after TGF-β1 treatment. In addition, anti-TGF-β1 antibodies could aggregate the cytotoxicity of dNK cells and the levels of molecules above. These results indicated that TGF-β1 treatment could improve the abnormal pregnancy outcomes with T. gondii infection by decreasing the cytotoxicity of dNK cells mediated by NKG2D/DAP10 pathway and killer subset. These results suggested that TGF-β1 might be a potential immunoprotective method for the treatment of abnormal pregnancy outcomes following T. gondii infection.Entities:
Keywords: Decidual NK cells; Killer subset of dNK; NKG2D/DAP10; TGF-β1; Toxoplasma gondii; dNK cytotoxicity
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Year: 2017 PMID： 28438315 DOI： 10.1016/j.cellimm.2017.04.004
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868