Silvia Ferronato1, Aldo Mombello2, Ilaria Posenato2, Paola Candiani3, Alberto Scuro3, Carlo Setacci4, Macarena Gomez-Lira1. 1. 1 Department of Neurological, Biomedical and Movement Sciences, University of Verona , Verona, Italy . 2. 2 Department of Diagnostics and Public Health, University of Verona , Verona, Italy . 3. 3 Department of Surgery, University of Verona , Verona, Italy . 4. 4 Division of Vascular Surgery, University of Siena , Siena, Italy .
Abstract
AIMS: The miR-17-92 cluster and the HDAC9 gene are involved in inflammatory, apoptotic, and angiogenic processes that are activated in the vulnerable carotid plaque. The aim of this research was to determine whether expression of one or more of the miRs of the miR-17-92 cluster and/or HDAC9 expression could represent biomarkers for patients with unstable atherosclerotic carotid plaques. MATERIALS AND METHODS: Plasma levels of miRs and HDAC9 expression in peripheral blood were analyzed by real-time PCR in patients with histologically classified stable or unstable plaques. RESULTS: No differences were observed between the two groups. DISCUSSION AND CONCLUSIONS: Levels of the miR-17-92 cluster in plasma and HDAC9 gene expression in peripheral blood cannot be considered appropriate biomarkers to identify patients with unstable plaques at risk of rupture.
AIMS: The miR-17-92 cluster and the HDAC9 gene are involved in inflammatory, apoptotic, and angiogenic processes that are activated in the vulnerable carotid plaque. The aim of this research was to determine whether expression of one or more of the miRs of the miR-17-92 cluster and/or HDAC9 expression could represent biomarkers for patients with unstable atherosclerotic carotid plaques. MATERIALS AND METHODS: Plasma levels of miRs and HDAC9 expression in peripheral blood were analyzed by real-time PCR in patients with histologically classified stable or unstable plaques. RESULTS: No differences were observed between the two groups. DISCUSSION AND CONCLUSIONS: Levels of the miR-17-92 cluster in plasma and HDAC9 gene expression in peripheral blood cannot be considered appropriate biomarkers to identify patients with unstable plaques at risk of rupture.
Authors: Yan Wen; Yao Chun; Zhong Qing Lian; Zhang Wei Yong; Yang Mei Lan; Liao Huan; Chen Yi Xi; Li Shu Juan; Zhong Wen Qing; Cheng Jia; Zhang Huan Ji Journal: Mol Med Rep Date: 2021-03-02 Impact factor: 2.952