Literature DB >> 284365

Humoral factor that specifically regulates prothrombin (factor II) levels (coagulopoietin-II).

M Karpatkin, S Karpatkin.   

Abstract

Prothrombin (Factor II) was decreased in rabbits by injection of a goat antiserum to prothrombin. When plasma from these rabbits was injected into normal animals, circulating prothrombin increased in the recipients, suggesting transfer of a humoral regulating factor ("coagulopoietin-II"). This coagulopoietin-II resisted boiling for 20 min. On Sephadex G-50 gel filtration, it remained in the retained volume, suggesting a molecular weight of less than 30,000. In an in vitro liver system, prothrombin increased in the incubation medium in the presence of coagulopoietin-II.

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Year:  1979        PMID： 284365      PMCID： PMC382967          DOI： 10.1073/pnas.76.1.491

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent.

Authors:  E W Friedman; M Karpatkin; S Karpatkin
Journal:  Blood       Date:  1976-12       Impact factor: 22.113

2.  Gamma-carboxyglutamic acid: identification and distribution in vitamin K-dependent proteins.

Authors:  G L Nelsestuen; T H Zytkovicz; J B Howard
Journal:  Mayo Clin Proc       Date:  1974-12       Impact factor: 7.616

3.  The nature of the heterogeneity of prothrombin during dicoumarol therapy.

Authors:  S A Morrison; M P Esnouf
Journal:  Nat New Biol       Date:  1973-03-21

4.  Evidence for a humoral agent capable of raising vitamin-K-dependent coagulation factors in rabbits.

Authors:  M Karpatkin; S Karpatkin
Journal:  Br J Haematol       Date:  1973-05       Impact factor: 6.998

5.  The purification of human prothrombin.

Authors:  S S Shapiro; D F Waugh
Journal:  Thromb Diath Haemorrh       Date:  1966-12-01

6.  Vitamin K dependent modifications of glutamic acid residues in prothrombin.

Authors:  J Stenflo; P Fernlund; W Egan; P Roepstorff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205
  6 in total
  2 in total

1.  Humoral factor that specifically regulates factor X levels in rabbits (coagulopoietin-X).

Authors:  D Trauber; K Hawkins; M Karpatkin; S Karpatkin
Journal:  J Clin Invest       Date:  1979-12       Impact factor: 14.808

2.  Induction of prothrombin synthesis by prothrombin fragments.

Authors:  C B Graves; T W Munns; T L Carlisle; G A Grant; A W Strauss
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205
  2 in total

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