Literature DB >> 284361

Another approach to in vivo estimation of genetic damage in humans.

R W Pero, F Mitelman.   

Abstract

Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.

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Year:  1979        PMID： 284361      PMCID： PMC382960          DOI： 10.1073/pnas.76.1.462

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Lymphocyte chromosome studies in humans exposed to chemical mutagens. The validity of the method in 67 patients under cytostatic therapy.

Authors:  A Schinzel; W Schmid
Journal:  Mutat Res       Date:  1976-04       Impact factor: 2.433

Review 2.  Evaluation of short-term tests for carcinogenicity.

Authors:  D R Stoltz; L A Poirier; C C Irving; H F Stich; J H Weisburger; H C Grice
Journal:  Toxicol Appl Pharmacol       Date:  1974-08       Impact factor: 4.219

3.  Preferential DNA repair in human cells.

Authors:  R J Wilkins; R W Hart
Journal:  Nature       Date:  1974-01-04       Impact factor: 49.962

4.  The repair of x-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytes.

Authors:  S Wolff
Journal:  Mutat Res       Date:  1972-08       Impact factor: 2.433

5.  Chromosome aberrations and metronidazole.

Authors:  F Mitelman; B Hartley-Asp; B Ursing
Journal:  Lancet       Date:  1976-10-09       Impact factor: 79.321

6.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

Authors:  G M Williams
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

7.  Chromosome aberrations in chronic alcoholics.

Authors:  F Mitelman; J Wadstein
Journal:  Lancet       Date:  1978-01-28       Impact factor: 79.321

8.  Interindividual variation in the responses of cultured human lymphocytes to exposure from DNA damaging chemical agents: interindividual variation to carcinogen exposure.

Authors:  R W Pero; C Bryngelsson; F Mitelman; R Kornfält; T Thulin; A Norden
Journal:  Mutat Res       Date:  1978-06       Impact factor: 2.433

9.  High blood pressure related to carcinogen-induced unscheduled DNA synthesis, DNA carcinogen binding, and chromosomal aberrations in human lymphocytes.

Authors:  R W Pero; C Bryngelsson; F Mitelman; T Thulin; A Nordén
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

10.  Differences in removal of acetylaminofluorene and pyrimidine dimers from the DNA of cultured mammalian cells.

Authors:  D E Amacher; J A Elliott; M W Lieberman
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205
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