| Literature DB >> 28435027 |
Ivy Reichert Vital da Silva1, Cintia Laura Pereira de Araujo2, Gilson Pires Dorneles3, Alessandra Peres4, Andreia Luciana Bard5, Gustavo Reinaldo2, Paulo José Zimermann Teixeira6, Pedro Dal Lago2, Viviane Rostirola Elsner7.
Abstract
The study investigated the effects of exercise on epigenetic signals and systemic cytokine levels in chronic obstructive pulmonary disease (COPD) individuals. Ten participants of a pulmonary rehabilitation program were submitted to 24 sessions of a supervisioned exercise protocol thrice-weekly (90min/session). Blood samples were collected at baseline, after the 1st session, before and after the 24th session. A DNA hypomethylation status was observed after the 1st session when compared at baseline, while global histone H4 acetylation status was unaltered in any time-points evaluated. No significant changes were observed on cytokine levels after the 1st session. A significant enhancement on interleukin 6 (IL-6) and a decrease on transforming growth factor-beta (TGF-β) levels were found after the 24th session when compared to the pre 24th session. Moreover, 23 sessions of exercise were able to diminish significantly the basal levels of IL-6 and interleukin 8 (IL-8). These data suggest a potential role of epigenetic machinery in mediating the anti-inflammatory effects of exercise in COPD patients.Entities:
Keywords: COPD; Exercise; Global DNA methylation; Global histone H4 acetylation; Inflammatory response
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Year: 2017 PMID： 28435027 DOI： 10.1016/j.resp.2017.04.004
Source DB: PubMed Journal: Respir Physiol Neurobiol ISSN： 1569-9048 Impact factor: 1.931