Literature DB >> 2843411

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages.

K U Lee1, C Y Pak, K Amano, J W Yoon.   

Abstract

Diabetes-prone biobreeding (BB) rats often develop lymphocytic thyroiditis. Intraperitoneal administration of silica to young BB rats (40-days-old) nearly completely prevented the development of lymphocytic thyroiditis as well as insulitis. Since silica is known to be toxic to macrophages, these data suggest that the presentation of autoantigen(s) on the specific target cells such as thyroid and pancreatic B cells by antigen-presenting cells (e.g., macrophages) would be the initial step in the development of organ-specific autoimmune diseases in diabetes-prone BB rats.

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Year:  1988        PMID： 2843411     DOI： 10.1007/BF02341511

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  6 in total

Review 1.  The basis for the immunoregulatory role of macrophages and other accessory cells.

Authors:  E R Unanue; P M Allen
Journal:  Science       Date:  1987-05-01       Impact factor: 47.728

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Authors:  E J O'Rourke; S B Halstead; A C Allison; T A Platts-Mills
Journal:  J Immunol Methods       Date:  1978       Impact factor: 2.303

3.  Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB.

Authors:  G B Toews; P R Bergstresser; J W Streilein
Journal:  J Immunol       Date:  1980-01       Impact factor: 5.422

Review 4.  The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man.

Authors:  E B Marliss; A F Nakhooda; P Poussier; A A Sima
Journal:  Diabetologia       Date:  1982-04       Impact factor: 10.122

5.  Phenotypic transformation of macrophages to Langerhans cells in the skin.

Authors:  G F Murphy; D Messadi; E Fonferko; W W Hancock
Journal:  Am J Pathol       Date:  1986-06       Impact factor: 4.307

6.  Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy.

Authors:  E Sternthal; A A Like; K Sarantis; L E Braverman
Journal:  Diabetes       Date:  1981-12       Impact factor: 9.461
  6 in total
  13 in total

1.  Low incidence of autoimmune type I diabetes in BB rats fed a hydrolysed casein-based diet associated with early inhibition of non-macrophage-dependent hyperexpression of MHC class I molecules on beta cells.

Authors:  X B Li; F W Scott; Y H Park; J W Yoon
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

2.  In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.

Authors:  Boris Calderon; Anish Suri; Emil R Unanue
Journal:  Am J Pathol       Date:  2006-12       Impact factor: 4.307

3.  Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages.

Authors:  T J Wilkin
Journal:  Diabetologia       Date:  1988-10       Impact factor: 10.122

Review 4.  The immunologic insult in type 1 diabetes.

Authors:  M C Honeyman; L C Harrison
Journal:  Springer Semin Immunopathol       Date:  1993

5.  Studies on autoimmunity for initiation of beta-cell destruction. VIII. Pancreatic beta-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats.

Authors:  I Y Ko; S H Ihm; J W Yoon
Journal:  Diabetologia       Date:  1991-08       Impact factor: 10.122

6.  Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

Authors:  A Hänninen; S Jalkanen; M Salmi; S Toikkanen; G Nikolakaros; O Simell
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

7.  Circulating monocytes are activated in newly diagnosed type 1 diabetes mellitus patients.

Authors:  K Josefsen; H Nielsen; S Lorentzen; P Damsbo; K Buschard
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330

8.  Studies on autoimmunity for initiation of beta-cell destruction. X. Delayed expression of a membrane-bound islet cell-specific 38 kDa autoantigen that precedes insulitis and diabetes in the diabetes-prone BB rat.

Authors:  I Y Ko; H S Jun; G S Kim; J W Yoon
Journal:  Diabetologia       Date:  1994-05       Impact factor: 10.122

9.  Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats.

Authors:  H Hanenberg; V Kolb-Bachofen; G Kantwerk-Funke; H Kolb
Journal:  Diabetologia       Date:  1989-02       Impact factor: 10.122

10.  Oral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice.

Authors:  Akihiro Uchida; Taro Yasuma; Atsuro Takeshita; Masaaki Toda; Yuko Okano; Kota Nishihama; Corina N D'Alessandro-Gabazza; Valeria Fridman D'Alessandro; Chisa Inoue; Takehiro Takagi; Hiroyuki Mukaiyama; Norio Takagi; Katsumi Shimizu; Yutaka Yano; Esteban C Gabazza
Journal:  J Inflamm Res       Date:  2021-07-09
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