HyunJung Lee1, Eue-Keun Choi1, Tae-Min Rhee1, So-Ryoung Lee1, Woo-Hyun Lim2, Si-Hyuck Kang3, Kyung-Do Han4, Myung-Jin Cha1, Seil Oh1. 1. Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. 2. Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea. 3. Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea. 4. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
BACKGROUND & AIMS: Information is lacking regarding whether cirrhosis is associated with atrial fibrillation development. We aimed to investigate the incidence and clinical significance of atrial fibrillation in cirrhotic patients. METHODS: Cirrhotic patients (n=3596; mean age, 54.7±12.3 years; male, 72.5%) without previous atrial fibrillation were selected from the Korean National Health Insurance Service National Sample Cohort database between 2004 and 2008. Age- and sex-matched controls (n=17 980) were randomly sampled in a 5:1 ratio from non-cirrhotic individuals. Both cohorts were followed up for incident atrial fibrillation and death until 2013. RESULTS: During 9 years of follow-up, atrial fibrillation was newly detected in 113 (3.1%) cirrhosis patients and 385 (2.1%) controls (incidence: 3.48 and 2.16 per 1000 person-years respectively). Cirrhotic patients were at higher risk for atrial fibrillation development compared to controls (hazard ratio, 1.46; 95% confidence interval, 1.18-1.80) after multivariate adjustment. On subgroup analysis, cirrhosis increased the risk for atrial fibrillation, especially in younger (age younger than 65 years) men without comorbidities (CHA2 DS2 -VASc score, 0). Cirrhotic patients showed increased overall mortality compared to controls (hazard ratio, 4.80; 95% confidence interval, 4.47-5.15) as well as increased cardiovascular mortality (hazard ratio, 1.37; 95% confidence interval, 1.07-1.75). However, there was no significant association between development of atrial fibrillation and increased mortality in cirrhosis patients (P=.188 and .260). CONCLUSIONS: Cirrhosis was an independent risk factor for atrial fibrillation development, especially in younger, otherwise healthy men, stressing the importance of cardiac assessment in cirrhotic patients. Meanwhile, atrial fibrillation development in cirrhosis patients was not associated with increased mortality.
BACKGROUND & AIMS: Information is lacking regarding whether cirrhosis is associated with atrial fibrillation development. We aimed to investigate the incidence and clinical significance of atrial fibrillation in cirrhotic patients. METHODS: Cirrhotic patients (n=3596; mean age, 54.7±12.3 years; male, 72.5%) without previous atrial fibrillation were selected from the Korean National Health Insurance Service National Sample Cohort database between 2004 and 2008. Age- and sex-matched controls (n=17 980) were randomly sampled in a 5:1 ratio from non-cirrhotic individuals. Both cohorts were followed up for incident atrial fibrillation and death until 2013. RESULTS: During 9 years of follow-up, atrial fibrillation was newly detected in 113 (3.1%) cirrhosispatients and 385 (2.1%) controls (incidence: 3.48 and 2.16 per 1000 person-years respectively). Cirrhotic patients were at higher risk for atrial fibrillation development compared to controls (hazard ratio, 1.46; 95% confidence interval, 1.18-1.80) after multivariate adjustment. On subgroup analysis, cirrhosis increased the risk for atrial fibrillation, especially in younger (age younger than 65 years) men without comorbidities (CHA2 DS2 -VASc score, 0). Cirrhotic patients showed increased overall mortality compared to controls (hazard ratio, 4.80; 95% confidence interval, 4.47-5.15) as well as increased cardiovascular mortality (hazard ratio, 1.37; 95% confidence interval, 1.07-1.75). However, there was no significant association between development of atrial fibrillation and increased mortality in cirrhosispatients (P=.188 and .260). CONCLUSIONS:Cirrhosis was an independent risk factor for atrial fibrillation development, especially in younger, otherwise healthy men, stressing the importance of cardiac assessment in cirrhotic patients. Meanwhile, atrial fibrillation development in cirrhosispatients was not associated with increased mortality.
Authors: Neal S Parikh; Insu Koh; Lisa B VanWagner; Mitchell S V Elkind; Neil A Zakai; Mary Cushman Journal: J Stroke Cerebrovasc Dis Date: 2021-04-16 Impact factor: 2.677
Authors: Federica Galli; Lidia Borghi; Stefano Carugo; Marco Cavicchioli; Elena Maria Faioni; Maria Silvia Negroni; Elena Vegni Journal: PeerJ Date: 2017-08-11 Impact factor: 2.984