Literature DB >> 2843219

Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U).

J Orellana1, S A Teich, J S Winterkorn, U Mathur-Wagh, S Handwerger, H Schlamm, S C Malamud, S R Yancovitz, D M Cederberg, D S Mildvan.   

Abstract

Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.

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Year:  1988        PMID： 2843219      PMCID： PMC1041518          DOI： 10.1136/bjo.72.7.525

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  30 in total

1.  Cytomegalic inclusion disease uveitis; report of a case with isolation from aqueous humor of the virus in tissue culture.

Authors:  R P BURNS
Journal:  AMA Arch Ophthalmol       Date:  1959-03

2.  Adult cytomegalovirus inclusion retino-uveitis.

Authors:  L C Chumbley; D M Robertson; T F Smith; R J Campbell
Journal:  Am J Ophthalmol       Date:  1975-11       Impact factor: 5.258

3.  9-(1,3-Dihydroxy-2-propoxymethyl)guanine for cytomegalovirus infections in patients with the acquired immunodeficiency syndrome.

Authors:  M C Bach; S P Bagwell; N P Knapp; K M Davis; P S Hedstrom
Journal:  Ann Intern Med       Date:  1985-09       Impact factor: 25.391

4.  Adult cytomegalic inclusion retinitis.

Authors:  G J Wyhinny; D J Apple; F R Guastella; C M Vygantas
Journal:  Am J Ophthalmol       Date:  1973-11       Impact factor: 5.258

5.  Correlation of virology and clinical course of cytomegalovirus retinitis.

Authors:  T M Aaberg; T J Cesarz; M W Rytel
Journal:  Am J Ophthalmol       Date:  1972-09       Impact factor: 5.258

6.  Cytomegalovirus in tears from patients with normal eyes and with acute cytomegalovirus chorioretinitis.

Authors:  F Cox; D Meyer; W T Hughes
Journal:  Am J Ophthalmol       Date:  1975-11       Impact factor: 5.258

7.  Viral particles in the conjunctiva of a patient with the acquired immune deficiency syndrome.

Authors:  S A Teich; S Tay; A H Friedman; M E Schmitterer
Journal:  Am J Med       Date:  1987-01       Impact factor: 4.965

8.  Antiviral therapy for cytomegalovirus retinitis in AIDS with dihydroxy propoxymethyl guanine.

Authors:  L R Rosecan; C M Stahl-Bayliss; C M Kalman; O L Laskin
Journal:  Am J Ophthalmol       Date:  1986-04-15       Impact factor: 5.258

9.  Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine.

Authors:  A G Palestine; G Stevens; H C Lane; H Masur; L S Fujikawa; R B Nussenblatt; A H Rook; J Manischewitz; B Baird; M Megill
Journal:  Am J Ophthalmol       Date:  1986-01-15       Impact factor: 5.258

10.  Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men.

Authors:  H Masur; H C Lane; A Palestine; P D Smith; J Manischewitz; G Stevens; L Fujikawa; A M Macher; R Nussenblatt; B Baird
Journal:  Ann Intern Med       Date:  1986-01       Impact factor: 25.391
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  2 in total

1.  Treatment of cytomegalovirus retinitis with zidovudine and ganciclovir in patients with AIDS: outcome and toxicity.

Authors:  A B Millar; R F Miller; G Patou; A Mindel; R Marsh; S J Semple
Journal:  Genitourin Med       Date:  1990-06

Review 2.  Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet.

Authors:  W J Keijer; D M Burger; G H Neuteboom; J L Vrooland; P L Meenhorst; C H Koks; J H Beijnen
Journal:  Pharm World Sci       Date:  1993-04-23
  2 in total

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