| Literature DB >> 28431877 |
Shunyi Wang1, Wuji Sun1, Qin Hu1, Hong Yan2, Yi Zeng1.
Abstract
The unique properties of polyoxometalates, such as molecular polarity, redox potential, surface charge distribution, shape and acidity, influence their response of recognition to targeted biological macromolecules. By using PM-19 (K7PTi2W10O40) as a lead-compound, a series of novel pyridinium polyoxometalates (A7PTi2W10O40), which hadn't been reported in literatures, were designed and synthesized. The evaluation was conducted using the single-cycle pseudovirus infection assay (TZM-bl assay), CCK-8 method was used for determining the cytotoxicity. The results indicated that the designed pyridinium polyoxometalates had a lower toxicity to TZM-bl cells, and showed higher inhibitory activity against HIV-1 virus.Entities:
Keywords: Human immunodeficiency virus; Pyridinium polyoxometalates; Synthesis; TZM-bl assay
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Year: 2017 PMID： 28431877 DOI： 10.1016/j.bmcl.2017.04.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823