Haifeng Wang1, Hongshi Cao2, Xiaohong Zhang3, Liang Ge4, Li Bie5. 1. Department of Neurosurgery of the First Clinical Hospital, Jilin University, Changchun, China. Electronic address: hfwangjl@sina.com. 2. Department of Neurosurgery of the First Clinical Hospital, Jilin University, Changchun, China. Electronic address: hscaoneuro@126.com. 3. Department of Neurosurgery of the First Clinical Hospital, Jilin University, Changchun, China. Electronic address: jlxiaohong@yeah.net. 4. Department of Neurosurgery of the First Clinical Hospital, Jilin University, Changchun, China. Electronic address: lianggedr@sina.com. 5. Department of Neurosurgery of the First Clinical Hospital, Jilin University, Changchun, China; Department of Pathology and Laboratory Medicine, University of California, Irvine, USA. Electronic address: bieli@aliyun.com.
Abstract
BACKGROUND:Hyperosmolar therapy, using either hypertonic saline (HTS) or mannitol (MT), is considered the treatment of choice for intracranial hypertension, a disorder characterized by high intracranial pressure (ICP). However, hyperosmolar agents have been postulated to impair coagulation and platelet function. The aim of this study was to identify whether HTS and MT could affect coagulation in moderate traumatic brain injury (TBI) patients. METHODS: In this prospective and randomized double-blind study, we included adult patients with moderate TBI. Patients were divided into two groups according to the type of hypertonic solution administered. Group A patients received 20% MT and group B patients received 3% HTS. Rotational thromboelastometry (ROTEM) parameters were used to assess coagulation and platelet function. RESULTS: ROTEM parameters included CT (clotting time), CFT (clot formation time), maximum clot firmness (MCF) measured by MCF (EXTEM and INTEM), MCF (FIBTEM) and standard coagulation tests (p>0.05). No significant differences were found between the two groups. Moreover, ROTEM parameters did not show significant changes at different time points after administration of the hyperosmolar solutions (p>0.05). Conclusions Overall, use of 3% HTS and 20% MT for the control of ICP did not significantly affect patients' coagulation function. Therefore, hyperosmotic solution is safe and does not increase the risk of intracranial rebleeding.
RCT Entities:
BACKGROUND: Hyperosmolar therapy, using either hypertonic saline (HTS) or mannitol (MT), is considered the treatment of choice for intracranial hypertension, a disorder characterized by high intracranial pressure (ICP). However, hyperosmolar agents have been postulated to impair coagulation and platelet function. The aim of this study was to identify whether HTS and MT could affect coagulation in moderate traumatic brain injury (TBI) patients. METHODS: In this prospective and randomized double-blind study, we included adult patients with moderate TBI. Patients were divided into two groups according to the type of hypertonic solution administered. Group A patients received 20% MT and group B patients received 3% HTS. Rotational thromboelastometry (ROTEM) parameters were used to assess coagulation and platelet function. RESULTS: ROTEM parameters included CT (clotting time), CFT (clot formation time), maximum clot firmness (MCF) measured by MCF (EXTEM and INTEM), MCF (FIBTEM) and standard coagulation tests (p>0.05). No significant differences were found between the two groups. Moreover, ROTEM parameters did not show significant changes at different time points after administration of the hyperosmolar solutions (p>0.05). Conclusions Overall, use of 3% HTS and 20% MT for the control of ICP did not significantly affect patients' coagulation function. Therefore, hyperosmotic solution is safe and does not increase the risk of intracranial rebleeding.
Authors: Thomas Palmaers; Elke Krämer; Julia Hinsenkamp; Hendrik Eismann; Dirk Scheinichen; Paul Frank Journal: Turk J Anaesthesiol Reanim Date: 2019-02-19
Authors: Alexander Fletcher-Sandersjöö; Eric Peter Thelin; Marc Maegele; Mikael Svensson; Bo-Michael Bellander Journal: Neurocrit Care Date: 2021-04 Impact factor: 3.210
Authors: Julia R Coleman; Ernest E Moore; Christopher C Silliman; Gregory R Stettler; Geoffrey R Nunns; Jason M Samuels; Matthew G Bartley; Navin G Vigneshwar; Mitchell J Cohen; Miguel Fragoso; Angela Sauaia Journal: J Am Coll Surg Date: 2019-12-14 Impact factor: 6.532