Literature DB >> 2843166

The effect of the NADPH oxidase inhibitor diphenyleneiodonium on aerobic and anaerobic microbicidal activities of human neutrophils.

J A Ellis1, S J Mayer, O T Jones.   

Abstract

NADPH-dependent superoxide production by intact human neutrophils is inhibited by DPI (diphenyleneiodonium), when stimulated by either FMLP (N-formylmethionyl-leucyl-phenylalanine) or PMA (phorbol 12-myristate 13-acetate). Addition of 10 microM-DPI abolished the reduction of both the FAD and the cytochrome b components of the NADPH oxidase. DPI inhibition of the oxidase was associated with defective aerobic killing of staphylococci by human neutrophils. Anaerobic killing, phagocytosis, chemotaxis and motility were relatively unaffected by 10 microM-DPI. Degranulation of the azurophil and specific granules, induced by the soluble stimuli FMLP or PMA, and by particulate stimuli was decreased by the presence of DPI. The above effects of DPI on human neutrophils are similar to those found in chronic granulomatous disease.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2843166      PMCID： PMC1149085          DOI： 10.1042/bj2510887

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

Authors:  R D Nelson; P G Quie; R L Simmons
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel.

Authors:  L M Henderson; J B Chappell; O T Jones
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

3.  The isolation of granules from neutrophile polymorphonuclear leukocytes (PMN's).

Authors:  M Baggiolini
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

4.  Abnormal kinetics of degranulation in chronic granulomatous disease.

Authors:  S B Gold; D M Hanes; D P Stites; H H Fudenberg
Journal:  N Engl J Med       Date:  1974-08-15       Impact factor: 91.245

5.  A modified assay of neutrophil function: use of lysostaphin to differentiate defective phagocytosis from impaired intracellular killing.

Authors:  J S Tan; C Watanakunakorn; J P Phair
Journal:  J Lab Clin Med       Date:  1971-08

6.  Leukocyte migration agarose test for the assessment of human neutrophil chemotaxis. I. Effects of environmental factors on neutrophil migration under agarose.

Authors:  H Repo
Journal:  Scand J Immunol       Date:  1977       Impact factor: 3.487

7.  The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils.

Authors:  A W Segal; O T Jones
Journal:  Biochem J       Date:  1979-07-15       Impact factor: 3.857

8.  Indices of granulocyte activity in inflammatory bowel disease.

Authors:  S P Kane; A V Hoffbrand; G Neale
Journal:  Gut       Date:  1974-12       Impact factor: 23.059

9.  The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH.

Authors:  A W Segal; M Geisow; R Garcia; A Harper; R Miller
Journal:  Nature       Date:  1981-04-02       Impact factor: 49.962

10.  Kinetics of fusion of the cytoplasmic granules with phagocytic vacuoles in human polymorphonuclear leukocytes. Biochemical and morphological studies.

Authors:  A W Segal; J Dorling; S Coade
Journal:  J Cell Biol       Date:  1980-04       Impact factor: 10.539
View more
  51 in total

1.  Relationship of proton motive force and the F(0)F (1)-ATPase with bio-hydrogen production activity of Rhodobacter sphaeroides: effects of diphenylene iodonium, hydrogenase inhibitor, and its solvent dimethylsulphoxide.

Authors:  Lilit Hakobyan; Lilit Gabrielyan; Armen Trchounian
Journal:  J Bioenerg Biomembr       Date:  2012-06-12       Impact factor: 2.945

2.  Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing.

Authors:  Felipe A Dias; Ana Caroline P Gandara; Fernanda G Queiroz-Barros; Raquel L L Oliveira; Marcos H F Sorgine; Glória R C Braz; Pedro L Oliveira
Journal:  J Biol Chem       Date:  2013-10-30       Impact factor: 5.157

3.  Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase.

Authors:  Carlos H C Serezani; David M Aronoff; Sonia Jancar; Peter Mancuso; Marc Peters-Golden
Journal:  Blood       Date:  2005-02-17       Impact factor: 22.113

4.  Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.

Authors:  Mark J White; Jeffrey M Boyd; Alexander R Horswill; William M Nauseef
Journal:  Infect Immun       Date:  2014-01-22       Impact factor: 3.441

5.  Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

Authors:  A Nanda; S Grinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

Review 6.  NADPH oxidases: an overview from structure to innate immunity-associated pathologies.

Authors:  Arvind Panday; Malaya K Sahoo; Diana Osorio; Sanjay Batra
Journal:  Cell Mol Immunol       Date:  2014-09-29       Impact factor: 11.530

7.  Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E.

Authors:  Rostyslav R Panchuk; Lilya V Lehka; Alessio Terenzi; Bohdan P Matselyukh; Jürgen Rohr; Amit K Jha; Theresa Downey; Iryna J Kril; Irene Herbacek; Sushilla van Schoonhoven; Petra Heffeter; Rostyslav S Stoika; Walter Berger
Journal:  Free Radic Biol Med       Date:  2017-02-09       Impact factor: 7.376

8.  Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase.

Authors:  J A Ellis; A R Cross; O T Jones
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

9.  A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors.

Authors:  Kaizheng Gong; Zijian Li; Ming Xu; Jianhai Du; Zhizhen Lv; Youyi Zhang
Journal:  J Biol Chem       Date:  2008-08-04       Impact factor: 5.157

10.  Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo.

Authors:  Y X Wang; C I Poon; K S Poon; C C Pang
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.