Literature DB >> 28431127

Cytomegalovirus Kinetics Following Primary Infection in Healthy Women.

Michael S Forman1, Dhananjay Vaidya2,3, Oluwaseyi Bolorunduro4, Marie Diener-West4, Robert F Pass5, Ravit Arav-Boger6.   

Abstract

The kinetics of cytomegalovirus (CMV) DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time polymerase chain reaction assay of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89; 95% confidence interval [CI], 1.43-10.57), urine (6.36; 95% CI, 2.48-16.32), and whole blood (11.88; 95% CI, 4.12-34.20). Vaginal CMV shedding may provide a route for sexual and possibly perinatal transmission.
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Cytomegalovirus; US17 real-time PCR.; normal host; viral loads

Mesh：

Substances：

Year:  2017        PMID： 28431127      PMCID： PMC5461424          DOI： 10.1093/infdis/jix188

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real-time PCR: correlation of CMV in the vagina and adverse outcome of pregnancy.

Authors:  Kaori Tanaka; Hideto Yamada; Mashiho Minami; Soromon Kataoka; Kei Numazaki; Hisanori Minakami; Hiroyuki Tsutsumi
Journal:  J Med Virol       Date:  2006-06       Impact factor: 2.327

2.  Maternal cytomegalovirus excretion and perinatal infection.

Authors:  D W Reynolds; S Stagno; T S Hosty; M Tiller; C A Alford
Journal:  N Engl J Med       Date:  1973-07-05       Impact factor: 91.245

Review 3.  The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. I.

Authors:  T H Weller
Journal:  N Engl J Med       Date:  1971-07-22       Impact factor: 91.245

4.  Maternal cytomegalovirus infection and perinatal transmission.

Authors:  S Stagno; R F Pass; M E Dworsky; C A Alford
Journal:  Clin Obstet Gynecol       Date:  1982-09       Impact factor: 2.190

5.  Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding.

Authors:  K Hamprecht; J Maschmann; M Vochem; K Dietz; C P Speer; G Jahn
Journal:  Lancet       Date:  2001-02-17       Impact factor: 79.321

6.  Cytomegalovirus infection in sex partners: evidence for sexual transmission.

Authors:  H H Handsfield; S H Chandler; V A Caine; J D Meyers; L Corey; E Medeiros; J K McDougall
Journal:  J Infect Dis       Date:  1985-02       Impact factor: 5.226

7.  Effect of artemether-lumefantrine (Coartem) on cytomegalovirus urine viral load during and following treatment for malaria in children.

Authors:  Breanna Barger-Kamate; Michael Forman; Cheik Oumar Sangare; Aboubecrin Sedhigh A Haidara; Hamma Maiga; Dhananjay Vaidya; Abdoulaye Djimde; Ravit Arav-Boger
Journal:  J Clin Virol       Date:  2016-02-11       Impact factor: 3.168

8.  The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers.

Authors:  Woottichai Khamduang; Gonzague Jourdain; Wasna Sirirungsi; Prapaisri Layangool; Suparat Kanjanavanit; Pornsuda Krittigamas; Karin Pagdi; Rosalin Somsamai; Surat Sirinontakan; Temsiri Hinjiranandana; Wanna Ardonk; Suchat Hongsiriwon; Sirisak Nanta; Thitiporn Borkird; Marc Lallemant; Kenneth McIntosh; Nicole Ngo-Giang-Huong
Journal:  J Acquir Immune Defic Syndr       Date:  2011-10-01       Impact factor: 3.731

9.  Vaccine prevention of maternal cytomegalovirus infection.

Authors:  Robert F Pass; Changpin Zhang; Ashley Evans; Tina Simpson; William Andrews; Meei-Li Huang; Lawrence Corey; Janie Hill; Elizabeth Davis; Cynthia Flanigan; Gretchen Cloud
Journal:  N Engl J Med       Date:  2009-03-19       Impact factor: 91.245

10.  Cytomegalovirus infection in sexually active adolescents.

Authors:  Y M Sohn; M K Oh; K B Balcarek; G A Cloud; R F Pass
Journal:  J Infect Dis       Date:  1991-03       Impact factor: 5.226
View more
  9 in total

1.  Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees.

Authors:  Ravit Arav-Boger; Sallie R Permar; Cody S Nelson; Diana Vera Cruz; Melody Su; Guanhua Xie; Nathan Vandergrift; Robert F Pass; Michael Forman; Marie Diener-West; Katia Koelle
Journal:  J Virol       Date:  2019-02-19       Impact factor: 5.103

2.  Human cytomegalovirus (HCMV) long-term shedding and HCMV-specific immune response in pregnant women with primary HCMV infection.

Authors:  C Fornara; F Zavaglio; M Furione; A Sarasini; P d'Angelo; A Arossa; A Spinillo; D Lilleri; F Baldanti
Journal:  Med Microbiol Immunol       Date:  2022-08-12       Impact factor: 4.148

Review 3.  The Penis, the Vagina and HIV Risk: Key Differences (Aside from the Obvious).

Authors:  Rupert Kaul; Cindy M Liu; Daniel E Park; Ronald M Galiwango; Aaron A R Tobian; Jessica L Prodger
Journal:  Viruses       Date:  2022-05-27       Impact factor: 5.818

4.  Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus.

Authors:  Arun Kapoor; Ayan K Ghosh; Michael Forman; Xin Hu; Wenjuan Ye; Noel Southall; Juan Marugan; Robert F Keyes; Brian C Smith; David J Meyers; Marc Ferrer; Ravit Arav-Boger
Journal:  J Med Chem       Date:  2020-03-27       Impact factor: 7.446

5.  Prevalence, Magnitude, and Genotype Distribution of Urinary Cytomegalovirus (CMV) Shedding Among CMV-Seropositive Children and Adolescents in the United States.

Authors:  Jodie L White; Eshan U Patel; Alison G Abraham; Mary Kate Grabowski; Ravit Arav-Boger; Robin K Avery; Thomas C Quinn; Aaron A R Tobian
Journal:  Open Forum Infect Dis       Date:  2019-06-05       Impact factor: 3.835

6.  Cytomegalovirus shedding in seropositive healthy women of reproductive age in Tianjin, China.

Authors:  D Ju; X Z Li; Y F Shi; Y Li; L Q Guo; Y Zhang
Journal:  Epidemiol Infect       Date:  2020-02-19       Impact factor: 2.451

7.  The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides.

Authors:  Xin Guo; Ayan Kumar Ghosh; Robert F Keyes; Francis Peterson; Michael Forman; David J Meyers; Ravit Arav-Boger
Journal:  Viruses       Date:  2022-01-25       Impact factor: 5.048

8.  A Novel Multiplexed Enzyme-Linked Immunosorbent Assay for the Detection of IgG Seroreactivity to Cytomegalovirus (CMV) UL144.

Authors:  H Miller; P Simpson; M Forman; A Prigan; S Kehl; B Mesich; M Faron; N Ledeboer; R Arav-Boger
Journal:  J Clin Microbiol       Date:  2021-07-19       Impact factor: 5.948

9.  Zika Virus Persistently and Productively Infects Primary Adult Sensory Neurons In Vitro.

Authors:  Brianna K Swartwout; Marta G Zlotnick; Ashley E Saver; Caroline M McKenna; Andrea S Bertke
Journal:  Pathogens       Date:  2017-10-13
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.