Adrian A Trenholme1, Emma J Best2,3, Alison M Vogel1, Joanna M Stewart4, Charissa J Miller1, Diana R Lennon1,2,3. 1. Kidz First, Counties Manukau District Health Board, Auckland, New Zealand. 2. Department of Paediatrics, University of Auckland, Auckland, New Zealand. 3. Paediatric Infectious Diseases Department, Starship Children's Hospital, Auckland District Health Board, Auckland, New Zealand. 4. Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand.
Abstract
AIM: To describe respiratory virus detection in children under 2 years of age in a population admitted with lower respiratory infection and to assess correlation with measures of severity. METHODS: Nasopharyngeal aspirates from infants admitted with lower respiratory tract infection (n = 1645) over a 3-year time period were tested by polymerase chain reaction. We collected epidemiological and clinical data on all children. We assessed the correlation of presence of virus with length of hospital stay, intensive care admission and consolidation on chest X-ray. RESULTS: Of the children admitted 34% were Maori, 43% Pacific and 75% lived in areas in the bottom quintile for socio-economic deprivation. A virus was found in 94% of those tested including 30% with multiple viruses. Picornavirus was present in 59% including 34% as the sole virus. Respiratory syncytial virus was found in 39%. Virus co-detection was not associated with length of stay, chest X-ray changes or intensive care unit admission. CONCLUSION: In this disadvantaged predominately Maori and Pacific population, picornavirus is commonly found as a sole virus, respiratory syncytial virus is frequent but immunisation preventable influenza is infrequent. We did not find that co-detection of viruses was linked to severity.
AIM: To describe respiratory virus detection in children under 2 years of age in a population admitted with lower respiratory infection and to assess correlation with measures of severity. METHODS: Nasopharyngeal aspirates from infants admitted with lower respiratory tract infection (n = 1645) over a 3-year time period were tested by polymerase chain reaction. We collected epidemiological and clinical data on all children. We assessed the correlation of presence of virus with length of hospital stay, intensive care admission and consolidation on chest X-ray. RESULTS: Of the children admitted 34% were Maori, 43% Pacific and 75% lived in areas in the bottom quintile for socio-economic deprivation. A virus was found in 94% of those tested including 30% with multiple viruses. Picornavirus was present in 59% including 34% as the sole virus. Respiratory syncytial virus was found in 39%. Virus co-detection was not associated with length of stay, chest X-ray changes or intensive care unit admission. CONCLUSION: In this disadvantaged predominately Maori and Pacific population, picornavirus is commonly found as a sole virus, respiratory syncytial virus is frequent but immunisation preventable influenza is infrequent. We did not find that co-detection of viruses was linked to severity.
Authors: N Prasad; A A Trenholme; Q S Huang; M G Thompson; N Pierse; M A Widdowson; T Wood; R Seeds; S Taylor; C C Grant; E C Newbern Journal: Epidemiol Infect Date: 2018-07-26 Impact factor: 2.451
Authors: Namrata Prasad; E Claire Newbern; Adrian A Trenholme; Tim Wood; Mark G Thompson; Nayyereh Aminisani; Q Sue Huang; Cameron C Grant Journal: Epidemiol Infect Date: 2019-01 Impact factor: 2.451