| Literature DB >> 2842952 |
Abstract
In studies using mutants of HSV-1 (strain 17), which are defective in inducing the HSV-specific dUTPase, Fisher and Preston concluded that since this enzyme was not essential for HSV replication, it would not be useful as a target site for the development of antiviral agents. In this study, we demonstrate that while these mutants do not induce a HSV-specific dUTPase, they do not shut off cellular dUTPase activity in infected cells and that the cellular dUTPase can function in place of the HSV-induced enzyme during the replication process. Data are also presented that demonstrate that the HSV-induced dUTPase can be used as a target site for the development of specific antiviral compounds.Entities:
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Year: 1988 PMID： 2842952 DOI： 10.1016/0042-6822(88)90171-7
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616