Vanadium(V)-Induced Oxidative Cross-Coupling of Various Boron and Silyl Enolates.

Intermolecular oxidative cross-coupling of two different enolates is one of the most useful reactions to synthesize unsymmetrical 1,4-dicarbonyl compounds. In this study, the oxovanadium(V)-induced intermolecular oxidative cross-coupling of enolates afforded unsymmetrical 1,4-dicarbonyl compounds. Various boron and silyl enolates underwent the formation of ketone-ester, ester-ketone, ester-ester, amide-ketone and amide-ester coupling products . These results clearly show the versatility of the present oxidative cross-coupling protocol.