Literature DB >> 28429312

SOX11 regulates the pro-apoptosis signal pathway and predicts a favorable prognosis of mantle cell lymphoma.

Wenjuan Yang1,2, Yanying Wang1,3, Zhen Yu1, Zengjun Li1, Gang An1, Wei Liu1, Rui Lv1, Liping Ma2, Shuhua Yi4, Lugui Qiu5.   

Abstract

Sex-determining region Y-box 11 (SOX11) is an important diagnostic marker in mantle cell lymphoma (MCL). However, the direct oncogenic mechanisms and downstream effector pathways implicated in SOX11-driven transformation remain poorly understood. In the present study, we analyzed SOX11 expression in B-NHL, and used lentivirus-mediated RNA interference targeting SOX11 to investigate the resulting changes in cellular processes and the underlying mechanisms in MCL cell lines. We found that patients with higher SOX11 expression have superior overall survival (OS) and progression-free survival (PFS) compared to those with lower SOX11 expression. SOX11 silencing promotes proliferation and inhibiting apoptosis of MCL cell through caspase-9-3-7-PARP signaling, and desensitizes MCL cell to bortezomib. Conclusively, our data suggest that SOX11 represents a useful prognostic marker in mantle cell lymphoma.

Entities:  

Keywords:  Bortezomib; Mantle cell lymphoma; Prognosis; SOX11; Signal pathway

Mesh：

Substances：

Year:  2017        PMID： 28429312     DOI： 10.1007/s12185-017-2236-y

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  22 in total

1.  High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma.

Authors:  P-Y Kuo; V V Leshchenko; M J Fazzari; D Perumal; T Gellen; T He; J Iqbal; S Baumgartner-Wennerholm; L Nygren; F Zhang; W Zhang; K S Suh; A Goy; D T Yang; W-C Chan; B S Kahl; A K Verma; R D Gascoyne; E Kimby; B Sander; B H Ye; A M Melnick; S Parekh
Journal:  Oncogene       Date:  2014-03-31       Impact factor: 9.867

2.  The establishment of neuronal properties is controlled by Sox4 and Sox11.

Authors:  Maria Bergsland; Martin Werme; Michal Malewicz; Thomas Perlmann; Jonas Muhr
Journal:  Genes Dev       Date:  2006-12-15       Impact factor: 11.361

Review 3.  Mantle cell lymphoma: evolving management strategies.

Authors:  Elias Campo; Simon Rule
Journal:  Blood       Date:  2014-12-11       Impact factor: 22.113

4.  Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas.

Authors:  Bernd Weigle; Reinhard Ebner; Achim Temme; Sandra Schwind; Marc Schmitz; Andrea Kiessling; Michael A Rieger; Gabriele Schackert; Hans K Schackert; E Peter Rieber
Journal:  Oncol Rep       Date:  2005-01       Impact factor: 3.906

5.  Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

Authors:  Pallavi Bhattaram; Alfredo Penzo-Méndez; Elisabeth Sock; Clemencia Colmenares; Kotaro J Kaneko; Alex Vassilev; Melvin L Depamphilis; Michael Wegner; Véronique Lefebvre
Journal:  Nat Commun       Date:  2010-04-12       Impact factor: 14.919

6.  A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.

Authors:  J L Binet; A Auquier; G Dighiero; C Chastang; H Piguet; J Goasguen; G Vaugier; G Potron; P Colona; F Oberling; M Thomas; G Tchernia; C Jacquillat; P Boivin; C Lesty; M T Duault; M Monconduit; S Belabbes; F Gremy
Journal:  Cancer       Date:  1981-07-01       Impact factor: 6.860

7.  The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

Authors:  Peter Dy; Alfredo Penzo-Méndez; Hongzhe Wang; Carlos E Pedraza; Wendy B Macklin; Véronique Lefebvre
Journal:  Nucleic Acids Res       Date:  2008-04-10       Impact factor: 16.971

8.  SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma--a Nordic Lymphoma Group study.

Authors:  Lena Nordström; Sandra Sernbo; Patrik Eden; Kirsten Grønbaek; Arne Kolstad; Riikka Räty; Marja-Liisa Karjalainen; Christian Geisler; Elisabeth Ralfkiaer; Christer Sundström; Anna Laurell; Jan Delabie; Mats Ehinger; Mats Jerkeman; Sara Ek
Journal:  Br J Haematol       Date:  2014-03-29       Impact factor: 6.998

9.  High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival.

Authors:  Shuhua Yi; Dehui Zou; Chengwen Li; Shizhen Zhong; Weiwei Chen; Zengjun Li; Wenjie Xiong; Wei Liu; Enbin Liu; Rui Cui; Kun Ru; Peihong Zhang; Yan Xu; Gang An; Rui Lv; Junyuan Qi; Jianxiang Wang; Tao Cheng; Lugui Qiu
Journal:  Oncotarget       Date:  2015-12-08

10.  Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.

Authors:  S E Bodrug; B J Warner; M L Bath; G J Lindeman; A W Harris; J M Adams
Journal:  EMBO J       Date:  1994-05-01       Impact factor: 11.598
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  5 in total

1.  BPTF activates the MAPK pathway through coexpression with Raf1 to promote proliferation of T-cell lymphoma.

Authors:  Dongyu Bai; Yong Zhou; Fayan Shen; Dehong Gao; Wenhao Suo; Haiping Zhang; Heng Li
Journal:  Oncol Lett       Date:  2022-05-25       Impact factor: 3.111

2.  SOX11 expression as a MRD molecular marker for MCL in comparison with t(11;14) and IGH rearrangement.

Authors:  Małgorzata Szostakowska; Michał Szymczyk; Kalina Badowska; Barbara Tudek; Anna Fabisiewicz
Journal:  Med Oncol       Date:  2018-03-08       Impact factor: 3.064

3.  Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma.

Authors:  Yi Miao; Xiao-Hui Zhou; Jing-Jing Guo; Qian Sun; Ke Shi; Jia-Zhu Wu; Hua-Yuan Zhu; Li Wang; Lei Fan; Wei Xu; Jian-Yong Li
Journal:  Cancer Med       Date:  2019-04-13       Impact factor: 4.452

4.  Highly sensitive and specific in situ hybridization assay for quantification of SOX11 mRNA in mantle cell lymphoma reveals association of TP53 mutations with negative and low SOX11 expression.

Authors:  Birgit Federmann; Leonie Frauenfeld; Helga Pertsch; Vanessa Borgmann; Julia Steinhilber; Irina Bonzheim; Falko Fend; Leticia Quintanilla-Martinez
Journal:  Haematologica       Date:  2019-07-11       Impact factor: 9.941

Review 5.  Progress in molecular feature of smoldering mantle cell lymphoma.

Authors:  Panruo Jiang; Aakash Desai; Haige Ye
Journal:  Exp Hematol Oncol       Date:  2021-07-13
  5 in total

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