| Literature DB >> 28429259 |
V B Karyakin1,2, D S Vasil'ev1, I A Zhuravin1, A V Zaitsev1, L G Magazanik3,4.
Abstract
We studied early alterations in the GABAergic system of the rat hippocampus in the lithium-pilocarpine model of epilepsy. Twenty-four hours after the pilocarpine treatment, a decrease in the number of calretinin-positive interneurons was observed in the CA1 field of the hippocampus, whereas the number of parvalbumin-positive interneurons remained unchanged. The decreased levels of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67) and the membrane GABA transporter GAT1 were revealed using Western blot analysis. These data indicate an altered excitation/inhibition balance in the hippocampus with excitation dominance.Entities:
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Year: 2017 PMID： 28429259 DOI： 10.1134/S0012496617010045
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966