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Literature DB >> 28429258

Hormonal regulation of NK cell cytotoxic activity.

S V Shirshev¹, I V Nekrasova², O L Gorbunova², E G Orlova².

Abstract

The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.

Entities: Gene

Mesh：

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Year: 2017 PMID： 28429258 DOI： 10.1134/S0012496617010021

Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966

13 in total

Review 1. A quarter century of granzymes.

Authors: C L Ewen; K P Kane; R C Bleackley
Journal: Cell Death Differ Date: 2011-11-04 Impact factor: 15.828

2. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.

Authors: Carly R K Loeb; Jennifer L Harris; Charles S Craik
Journal: J Biol Chem Date: 2006-06-23 Impact factor: 5.157

3. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.

Authors: Jacob Hanna; Debra Goldman-Wohl; Yaron Hamani; Inbal Avraham; Caryn Greenfield; Shira Natanson-Yaron; Diana Prus; Leonor Cohen-Daniel; Tal I Arnon; Irit Manaster; Roi Gazit; Vladimir Yutkin; Daniel Benharroch; Angel Porgador; Eli Keshet; Simcha Yagel; Ofer Mandelboim
Journal: Nat Med Date: 2006-08-06 Impact factor: 53.440

4. The role of pregnancy-associated hormones in regulation of expression of molecules responsible for NK cell functional activity.

Authors: S V Shirshev; I V Nekrasova; S A Zamorina; O L Gorbunova; E G Orlova; I I Maslennikova
Journal: Dokl Biol Sci Date: 2014-08-30

5. Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype.

Authors: Hideto Yamada; Shigeki Shimada; Mamoru Morikawa; Kazuya Iwabuchi; Reiko Kishi; Kazunori Onoé; Hisanori Minakami
Journal: Mol Hum Reprod Date: 2005-06-13 Impact factor: 4.025

6. NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.

Authors: Marco Vitale; Alessandra Bassini; Paola Secchiero; Prisco Mirandola; Cristina Ponti; Loris Zamai; Adriana R Mariani; Mirella Falconi; Giacomo Azzali
Journal: Anat Rec Date: 2002-02-01

7. Decidual lymphocytes of human spontaneous abortions induce apoptosis but not necrosis in JEG-3 extravillous trophoblast cells.

Authors: Enrique G Olivares; Raquel Muñoz; Germán Tejerizo; María José Montes; Francisca Gómez-Molina; Ana Clara Abadía-Molina
Journal: Biol Reprod Date: 2002-10 Impact factor: 4.285

Review 8. Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents.

Authors: Shernan G Holtan; Douglas J Creedon; Paul Haluska; Svetomir N Markovic
Journal: Mayo Clin Proc Date: 2009-11 Impact factor: 7.616

Hormonal regulation of NK cell cytotoxic activity.

Review 1. A quarter century of granzymes.

2. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.

3. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.

4. The role of pregnancy-associated hormones in regulation of expression of molecules responsible for NK cell functional activity.

5. Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype.

6. NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.

7. Decidual lymphocytes of human spontaneous abortions induce apoptosis but not necrosis in JEG-3 extravillous trophoblast cells.

Review 8. Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents.

Review 9. Cell death mechanisms induced by cytotoxic lymphocytes.

10. A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1. NK cells associate with ALS in a sex- and age-dependent manner.

2. The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.

Review 3. Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer.