| Literature DB >> 28429257 |
T Ya Vakhitov1, N I Chalisova2, S I Sitkin3, T S Sall3, O N Shalaeva3, E V Demyanova1, A S Morugina1, A F Vinogradova4, A V Petrov1, A D Nozdrachev3,4.
Abstract
The effects of blood metabolites and model cell culture exometabolites found in the human and animal blood metabolomes have been assessed. Specifically, the influence of carboxylic acids that are structural analogues of amino acids and the drug Aktoflor-C have been studied. Methods of organotypic culturing of rat tissues and Escherichia coli bacterial culturing have been used. It has been found that all the tested compounds either stimulate or inhibit cell proliferation in tissue cultures and proliferation in bacterial cultures. The metabolites that are present in blood and interstitial fluids can exert regulation effects on the tissues of the body and intestinal microbiota.Entities:
Mesh：
Year: 2017 PMID： 28429257 DOI： 10.1134/S0012496617010069
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966