Valentina Pinzi1, Elena Biagioli2, Anna Roberto2, Francesca Galli2, Michele Rizzi3, Federica Chiappa2, Greta Brenna4, Laura Fariselli5, Irene Floriani2. 1. IRCCS Istituto Neurologico Fondazione Carlo Besta, Neurosurgery Department, Radiotherapy Unit, Via G. Celoria 11, 20133 Milan, Italy. Electronic address: valentina.pinzi@istituto-besta.it. 2. IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy. 3. IRCCS Istituto Neurologico Fondazione Carlo Besta, Neurosurgery Department, Via G. Celoria 11, 20133 Milan, Italy. 4. IRCCS Istituto Neurologico Fondazione Carlo Besta, Scientific Directorate, Via G. Celoria 11, 20133 Milan, Italy. 5. IRCCS Istituto Neurologico Fondazione Carlo Besta, Neurosurgery Department, Radiotherapy Unit, Via G. Celoria 11, 20133 Milan, Italy.
Abstract
BACKGROUND: Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. METHODS: Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. RESULTS: The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%-98.9% and 53.1%-97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. CONCLUSIONS: RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.
BACKGROUND: Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. METHODS: Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. RESULTS: The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%-98.9% and 53.1%-97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. CONCLUSIONS: RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.
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