Literature DB >> 28427500

Specificity protein 1: Its role in colorectal cancer progression and metastasis.

Richa Bajpai1, Ganji Purnachandra Nagaraju2.   

Abstract

Specificity protein 1 (Sp1) is a widely expressed transcription factor that plays an important role in the promotion of oncogenes required for tumor survival, progression and metastasis. Sp1 is highly expressed in several cancers including colorectal cancer (CRC) and is related to poor prognosis. Therefore, targeting Sp1 is a rational for CRC therapy. In this review, we will recapitulate the current understanding of Sp1 signaling, its molecular mechanisms, and its potential involvement in CRC growth, progression and metastasis. We will also discuss the current therapeutic drugs for CRC and their mechanism of action via Sp1.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cell survival; Colorectal cancer; Metastasis; Specificity protein 1

Mesh：

Substances：

Year:  2017        PMID： 28427500     DOI： 10.1016/j.critrevonc.2017.02.024

Source DB:  PubMed          Journal:  Crit Rev Oncol Hematol        ISSN： 1040-8428            Impact factor:   6.312


  22 in total

Review 1.  Transcription factors in colorectal cancer: molecular mechanism and therapeutic implications.

Authors:  Hui Xu; Lei Liu; Weilin Li; Duowu Zou; Jun Yu; Lifu Wang; Chi Chun Wong
Journal:  Oncogene       Date:  2020-12-15       Impact factor: 9.867

2.  Differential expression analysis of genes and long non-coding RNAs associated with KRAS mutation in colorectal cancer cells.

Authors:  Mahsa Saliani; Razieh Jalal; Ali Javadmanesh
Journal:  Sci Rep       Date:  2022-05-13       Impact factor: 4.996

3.  Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis.

Authors:  Ana Montero-Calle; Maricruz Sánchez-Martínez; Guillermo Solís-Fernández; Alberto Peláez-García; María Jesús Fernández-Aceñero; Pilar Pallarés; Miren Alonso-Navarro; Marta Mendiola; Jelle Hendrix; David Hardisson; Rubén A Bartolomé; Johan Hofkens; Susana Rocha; Rodrigo Barderas
Journal:  Br J Cancer       Date:  2022-03-28       Impact factor: 9.075

4.  A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner.

Authors:  Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang
Journal:  Angiogenesis       Date:  2021-01-23       Impact factor: 10.658

5.  MicroRNA-548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein 1.

Authors:  Haile Qiu; Gehong Zhang; Bin Song; Junmei Jia
Journal:  Exp Ther Med       Date:  2019-07-25       Impact factor: 2.751

6.  Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.

Authors:  Xinyu Zhang; Rui Li; Xiaoteng Qin; Lei Wang; Jie Xiao; Yu Song; Xi Sheng; Mengqi Guo; Xiaoping Ji
Journal:  J Am Heart Assoc       Date:  2018-03-23       Impact factor: 5.501

7.  MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1.

Authors:  Yupeng Ren; Hao Zhang; Peng Jiang
Journal:  Biol Res       Date:  2018-11-24       Impact factor: 5.612

8.  Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells.

Authors:  Laxminarayan Rawat; Vijayashree Nayak
Journal:  Toxicol Res (Camb)       Date:  2021-04-12       Impact factor: 3.524

Review 9.  A partnership with the proteasome; the destructive nature of GSK3.

Authors:  Holly Robertson; John D Hayes; Calum Sutherland
Journal:  Biochem Pharmacol       Date:  2017-11-01       Impact factor: 5.858

10.  SP1 Expression and the Clinicopathological Features of Tumors: A Meta-Analysis and Bioinformatics Analysis.

Authors:  Yue Gao; Kai Gan; Kuangzheng Liu; Bin Xu; Ming Chen
Journal:  Pathol Oncol Res       Date:  2021-01-28       Impact factor: 3.201
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