Literature DB >> 2842697

Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor.

C A Taylor1, C Tsai, J Lehmann.   

Abstract

KCl-, NMDA-, and glycine-evoked release of [3H]acetylcholine was studied in superfused rat striatal slices. KCl-evoked release of [3H]acetylcholine was inhibited by 1.2 mM MgCl2 and 100 microM lidocaine. Similarly, NMDA-evoked release was inhibited by MgCl2 and lidocaine as well as 10 microM CGS 19755, a competitive antagonist at NMDA receptors, and 10 nM MK-801, a noncompetitive antagonist of NMDA-induced responses. Glycine-evoked release was calcium-dependent and was inhibited by 0.1 microM strychnine whereas KCl- and NMDA-evoked release were resistant to strychnine. In addition, lidocaine inhibited the glycine-induced response. Cross-tachyphylaxis was not observed between NMDA- and glycine-evoked release. These results indicate that the strychnine-sensitive, glycine-evoked release of [3H]acetylcholine is independent of the NMDA receptor.

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Year:  1988        PMID： 2842697     DOI： 10.1007/BF00182730

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  15 in total

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Authors:  V Leviel; A Chéramy; A Nieoullon; J Glowinski
Journal:  Brain Res       Date:  1979-10-19       Impact factor: 3.252

6.  Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.

Authors:  J Lehmann; B Scatton
Journal:  Brain Res       Date:  1982-12-02       Impact factor: 3.252

7.  Effects of omega-amino acids on tritiated dopamine release from rat striatum: evidence for a possible glycinergic mechanism.

Authors:  R Kerwin; C Pycock
Journal:  Biochem Pharmacol       Date:  1979-07-15       Impact factor: 5.858

8.  Depolarizing responses to glycine, beta-alanine and muscimol in isolated optic nerve and cuneate nucleus.

Authors:  M A Simmonds
Journal:  Br J Pharmacol       Date:  1983-07       Impact factor: 8.739

9.  Glycine stimulates the spontaneous release of newly synthesized 3H-dopamine in rat striatal slices.

Authors:  M F Giorguieff-Chesselet; M L Kemel; D Wandscheer; J Glowinski
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Authors:  G Levi; G Bernardi; E Cherubini; V Gallo; M G Marciani; P Stanzione
Journal:  Brain Res       Date:  1982-03-18       Impact factor: 3.252
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Authors:  O Dudeck; S Lübben; S Eipper; R Knörle; M Kirsch; J Honegger; J Zentner; T J Feuerstein
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