Literature DB >> 28425866

Recent Development of Oridonin Derivatives with Diverse Pharmacological Activities.

Weiyan Cheng1, Chuanhui Huang2, Weifeng Ma3, Xin Tian1, Xiaojian Zhang1.   

Abstract

Oridonin is one of the major components isolated from Isodon rubescens, a traditional Chinese medicine, and it has been confirmed to exhibit many kinds of biological activities including anticancer, anti-inflammation, antibacterial and so on. However, the poor pharmaceutical property limits the clinical applications of oridonin. So many strategies have been explored in the purpose of improving the potencies of oridonin, and structure modification is one thus way. This review outlines the landscape of the recent development of oridonin derivatives with diverse pharmacological activities, mainly focusing on the biological properties, structure-activity relationships, and mechanism of actions. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Derivative; mechanism of action; oridonin; pharmaceutical activity; structure modification; structure-activity relationship.

Mesh：

Substances：

Year:  2019        PMID： 28425866     DOI： 10.2174/1389557517666170417170609

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  9 in total

1.  Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products.

Authors:  Yue Du; Yongliang Yuan; Le Xu; Fang Zhao; Wenbin Wang; Yiping Xu; Xin Tian
Journal:  Front Pharmacol       Date:  2022-04-27       Impact factor: 5.988

2.  Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.

Authors:  Baisen Zhong; Weiyu Peng; Shan Du; Bingyi Chen; Yajuan Feng; Xinfeng Hu; Qi Lai; Shujie Liu; Zhong-Wei Zhou; Pengfei Fang; Yan Wu; Feng Gao; Huihao Zhou; Litao Sun
Journal:  Small Sci       Date:  2022-03-13

Review 3.  Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer.

Authors:  Meizhu He; Lijie Xia; Jinyao Li
Journal:  Biomolecules       Date:  2021-10-18

4.  Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.

Authors:  Chunyan Li; Yuehua Zhu; Yuanyuan Wu; Meiyuan Fu; Yiling Wu; Yuehong Wu; Yinger Qiu; Hui Zhang; Mingxing Ding
Journal:  Front Med (Lausanne)       Date:  2022-01-12

5.  Oridonin Attenuates Burkholderia cenocepacia Virulence by Suppressing Quorum-Sensing Signaling.

Authors:  Xia Li; Kai Wang; Gerun Wang; Binbin Cui; Shihao Song; Xiuyun Sun; Yinyue Deng
Journal:  Microbiol Spectr       Date:  2022-07-20

6.  Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier.

Authors:  Gongsen Chen; Juyuan Luo; Mengru Cai; Liuying Qin; Yibo Wang; Lili Gao; Pingqing Huang; Yingchao Yu; Yangming Ding; Xiaoxv Dong; Xingbin Yin; Jian Ni
Journal:  Molecules       Date:  2019-09-16       Impact factor: 4.411

Review 7.  Solubility and Bioavailability Enhancement of Oridonin: A Review.

Authors:  Yuanyuan Zhang; Shaohua Wang; Mengmeng Dai; Jijuan Nai; Liqiao Zhu; Huagang Sheng
Journal:  Molecules       Date:  2020-01-14       Impact factor: 4.411

Review 8.  Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity.

Authors:  Xiang Li; Chuan-Tao Zhang; Wei Ma; Xin Xie; Qun Huang
Journal:  Front Pharmacol       Date:  2021-07-05       Impact factor: 5.810

9.  The antibacterial mechanism of oridonin against methicillin-resistant Staphylococcus aureus (MRSA).

Authors:  Zhongwei Yuan; Ping Ouyang; Kexin Gu; Tayyab Rehman; Tianyi Zhang; Zhongqiong Yin; Hualin Fu; Juchun Lin; Changliang He; Gang Shu; Xiaoxia Liang; Zhixiang Yuan; Xu Song; Lixia Li; Yuanfeng Zou; Lizi Yin
Journal:  Pharm Biol       Date:  2019-12       Impact factor: 3.503
  9 in total

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