Emrah Yilmaz1, Emine Tamer1, Ferda Artüz2, Seray Külcü Çakmak1, Fürüzan Köktürk3. 1. Clinic of Dermatology, Ankara Numune Education and Research Hospital, Ankara, Turkey. 2. Department of Dermatology, Faculty of Medicine, Hitit University, Çorum, Turkey. 3. Department of Biostatistics, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
Abstract
BACKGROUND/AIM: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. MATERIALS AND METHODS: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 healthy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients. RESULTS: Serum uric acid levels of psoriasis patients were significantly higher than those of controls. There was a positive correlation between PASI scores and serum uric acid levels of the patients. CONCLUSION: As hyperuricemia had a close relationship with psoriasis and PASI scores, we suggest monitoring patients with psoriasis for serum uric acid levels during treatment and follow-up.
BACKGROUND/AIM: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. MATERIALS AND METHODS: In this cross-sectional study, we evaluated 70 psoriasispatients and 70 healthy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients. RESULTS: Serum uric acid levels of psoriasispatients were significantly higher than those of controls. There was a positive correlation between PASI scores and serum uric acid levels of the patients. CONCLUSION: As hyperuricemia had a close relationship with psoriasis and PASI scores, we suggest monitoring patients with psoriasis for serum uric acid levels during treatment and follow-up.
Authors: Augusta Ortolan; Mariagrazia Lorenzin; Giulia Tadiotto; Francesco Paolo Russo; Francesca Oliviero; Mara Felicetti; Renata D'Incà; Marta Favero; Stefano Piaserico; Andrea Doria; Roberta Ramonda Journal: Clin Rheumatol Date: 2019-06-28 Impact factor: 2.980
Authors: Michelle L M Mulder; Tamara W van Hal; Mark H Wenink; Hans J P M Koenen; Frank H J van den Hoogen; Elke M G J de Jong; Juul M P A van den Reek; Johanna E Vriezekolk Journal: Arthritis Res Ther Date: 2021-06-14 Impact factor: 5.156