Akiko Ito1, Kazue Nishioka2, Hiromi Kanto3, Akiko Yagami4, Shigeki Yamada5, Mariko Sugiura6, Chihiro Yasunaga7, Keiko Yoshii8, Hiromi Kobayashi9, Atsuko Adachi10, Yuko Ikezawa11, Kumiko Washizaki3, Shigeki Inui12, Hitoshi Miyazawa13, Naoki Oiso14, Tokio Nakata15, Kayoko Matsunaga4,16. 1. Department of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8520, Japan. 2. Joy Dermatological Clinic, Sanyo-Onoda, 756-0000, Japan. 3. Department of Dermatology, Toho University Omori Medical Centre, Ohta-ku, 143-8541, Japan. 4. Department of Dermatology, Fujita Health University School of Medicine, Toyoake, 470-1100, Japan. 5. Department of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, 470-1100, Japan. 6. Department of Environmental Dermatology and Allergology, Daiichi Clinic, Nagoya, 450-0008, Japan. 7. Department of Dermatology, Gokeikai Osaka Kaisei Hospital, Ikeda, 532-0003, Japan. 8. Yoshii Clinic, Somuta, 890-0014, Japan. 9. Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, 558-8585, Japan. 10. Department of Dermatology, Hyogo Prefectural Kakogawa Medical Centre, Kakogawa, 675-8611, Japan. 11. Department of Dermatology, Chigasaki Municipal Hospital, Chigasaki, 253-0042, Japan. 12. Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan. 13. Nishi-Sapporo Skin and Allergy Clinic, Sapporo, 063-0061, Japan. 14. Faculty of Medicine, Department of Dermatology, Kindai University, Osakasayama, 589-0014, Japan. 15. Department of Dermatology, Showa University Fujigaoka Hospital, Yokohama, 227-8501, Japan. 16. Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Toyoake, 470-1100, Japan.
Abstract
BACKGROUND: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions. OBJECTIVES: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series. METHODS: We selected 19 hair cosmetic allergens, including PPD, Bandrowski's base, cysteamine HCl, and ammonium thioglycolate. Altogether 203 patients (26 males and 177 females) with suspected contact allergy to hair colouring or perming solutions at 14 hospitals in Japan were included. RESULTS: The highest prevalence of positive reactions (35.1%) was for PPD. p-Methylaminophenol and o-aminophenol were often positive, both in the PPD-positive and in the PPD-negative patients. Moreover, cysteamine HCl often yielded positive test reactions. CONCLUSIONS: PPD is insufficient to diagnose contact allergy caused by to hair dyes. We recommend 13 allergens to be included in a Japanese hairdresser series.
BACKGROUND: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions. OBJECTIVES: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series. METHODS: We selected 19 hair cosmetic allergens, including PPD, Bandrowski's base, cysteamine HCl, and ammonium thioglycolate. Altogether 203 patients (26 males and 177 females) with suspected contact allergy to hair colouring or perming solutions at 14 hospitals in Japan were included. RESULTS: The highest prevalence of positive reactions (35.1%) was for PPD. p-Methylaminophenol and o-aminophenol were often positive, both in the PPD-positive and in the PPD-negative patients. Moreover, cysteamine HCl often yielded positive test reactions. CONCLUSIONS:PPD is insufficient to diagnose contact allergy caused by to hair dyes. We recommend 13 allergens to be included in a Japanese hairdresser series.
Authors: Cara Symanzik; Patricia Weinert; Željka Babić; Sarah Hallmann; Martin Stibius Havmose; Jeanne Duus Johansen; Sanja Kezic; Marija Macan; Jelena Macan; Julia Strahwald; Rajka Turk; Henk F van der Molen; Swen Malte John; Wolfgang Uter Journal: Int J Environ Res Public Health Date: 2022-06-21 Impact factor: 4.614
Authors: Marie L Schuttelaar; Daan Dittmar; Johannes G M Burgerhof; Brunhilde Blömeke; Carsten Goebel Journal: Contact Dermatitis Date: 2018-08-07 Impact factor: 6.600