Euthimia Dimitriadou1, Christoforos D Giannaki2, Maria Tsekoura3, Ioannis Stefanidis4, Georgios M Hadjigeorgiou4, Eleftherios Lavdas5, Christina Karatzaferi3,6, Giorgos K Sakkas7,8. 1. Department of Haematology, General Hospital of Trikala, Trikala, Greece. 2. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. 3. Department of PE and Sport Science, University of Thessaly, Trikala, Greece. 4. School of Health Science, Department of Medicine, University of Thessaly, Larissa, Greece. 5. Department of Medical Radiological Technologists, Technological Education Institute of Athens, Athens, Greece. 6. Faculty of Sport and Health Sciences, School of Sport and Health Science, University of St Mark and St John, Derriford Rd, PL68BH, Plymouth, UK. 7. Department of PE and Sport Science, University of Thessaly, Trikala, Greece. gsakkas@marjon.ac.cy. 8. Faculty of Sport and Health Sciences, School of Sport and Health Science, University of St Mark and St John, Derriford Rd, PL68BH, Plymouth, UK. gsakkas@marjon.ac.cy.
Abstract
PURPOSE: Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling. In the present study, the aim was to explore the prevalence of RLS as well as to explore potential association between the syndrome and various quality of life-related parameters in a sample of beta thalassemia patients. METHODS: One hundred fourteen (age 40 ± 11 yr, 59 M/55F) beta thalassemia patients participated in this cross-sectional descriptive study. Patients were screened for RLS based on the international RLS study group diagnostic criteria as well as a battery of validated questionnaires. RESULTS: The prevalence of RLS in this sample of beta thalassemia patients was zero. The quality of life score was low (78 ± 18). Iron levels were within normal range (191 ± 66 mcg/dL) while ferritin levels were high as expected (1836 ± 225 ng/dL). CONCLUSIONS: Our sample of patients comes from central Greece where the prevalence of RLS in the general population is 4% while in renal failure patients is 27%. To our surprise, there was no presence of RLS among this sample of beta thalassemia patients. The adequate levels of iron and ferritin often seen in these patients could be the reason of the absence of RLS symptoms.
PURPOSE: Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling. In the present study, the aim was to explore the prevalence of RLS as well as to explore potential association between the syndrome and various quality of life-related parameters in a sample of beta thalassemiapatients. METHODS: One hundred fourteen (age 40 ± 11 yr, 59 M/55F) beta thalassemiapatients participated in this cross-sectional descriptive study. Patients were screened for RLS based on the international RLS study group diagnostic criteria as well as a battery of validated questionnaires. RESULTS: The prevalence of RLS in this sample of beta thalassemiapatients was zero. The quality of life score was low (78 ± 18). Iron levels were within normal range (191 ± 66 mcg/dL) while ferritin levels were high as expected (1836 ± 225 ng/dL). CONCLUSIONS: Our sample of patients comes from central Greece where the prevalence of RLS in the general population is 4% while in renal failurepatients is 27%. To our surprise, there was no presence of RLS among this sample of beta thalassemiapatients. The adequate levels of iron and ferritin often seen in these patients could be the reason of the absence of RLS symptoms.
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