| Literature DB >> 2842501 |
M P Wentland1, R B Perni, P H Dorff, J B Rake.
Abstract
A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.Entities:
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Year: 1988 PMID： 2842501 DOI： 10.1021/jm00117a005
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446