Literature DB >> 28424198

Pneumococcal Capsular Polysaccharide Immunity in the Elderly.

Hugh Adler1,2, Daniela M Ferreira3, Stephen B Gordon4, Jamie Rylance3,2,5.   

Abstract

Immunity to pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population. Naturally acquired immunity to pneumococcal capsular polysaccharides develops during childhood and is robust in young adults but deteriorates with advanced age. In particular, antibody levels and function are reduced in older people. Pneumococcal vaccines are recommended for people >65 years old. However, the benefits of polysaccharide and protein-conjugated vaccines in this population are small, because of both serotype replacement and incomplete protection against vaccine serotype pneumococcal disease. In this review, we overview the immune mechanisms by which naturally acquired and vaccine-induced pneumococcal capsular polysaccharide immunity declines with age, including altered colonization dynamics, reduced opsonic activity of antibodies (particularly IgM), and impaired mucosal immunity.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Streptococcus pneumoniae; aging; colonization; immunization; immunoglobulins; mucosal immunity; pneumococcus; pneumonia

Mesh：

Substances：

Year:  2017        PMID： 28424198      PMCID： PMC5461380          DOI： 10.1128/CVI.00004-17

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  113 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-02       Impact factor: 11.205

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Authors:  Joon Young Song; M Allen Moseley; Robert L Burton; Moon H Nahm
Journal:  J Infect Chemother       Date:  2013-05-09       Impact factor: 2.211

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Journal:  Lancet Respir Med       Date:  2013-09-18       Impact factor: 30.700

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Journal:  J Immunol       Date:  1988-06-01       Impact factor: 5.422

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Authors:  Takaya Maruyama; Osamu Taguchi; Michael S Niederman; John Morser; Hiroyasu Kobayashi; Tetsu Kobayashi; Corina D'Alessandro-Gabazza; Sei Nakayama; Kimiaki Nishikubo; Takashi Noguchi; Yoshiyuki Takei; Esteban C Gabazza
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Authors:  Goutam Sen; Quanyi Chen; Clifford M Snapper
Journal:  Infect Immun       Date:  2006-04       Impact factor: 3.441

9.  Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation.

Authors:  Jonathan M Cohen; Suneeta Khandavilli; Emilie Camberlein; Catherine Hyams; Helen E Baxendale; Jeremy S Brown
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10.  TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity.

Authors:  Alicja Puchta; Avee Naidoo; Chris P Verschoor; Dessi Loukov; Netusha Thevaranjan; Talveer S Mandur; Phuong-Son Nguyen; Manel Jordana; Mark Loeb; Zhou Xing; Lester Kobzik; Maggie J Larché; Dawn M E Bowdish
Journal:  PLoS Pathog       Date:  2016-01-14       Impact factor: 6.823
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  15 in total

1.  An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae.

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Journal:  mBio       Date:  2018-12-18       Impact factor: 7.867

Review 2.  Mechanisms of Naturally Acquired Immunity to Streptococcus pneumoniae.

Authors:  Elisa Ramos-Sevillano; Giuseppe Ercoli; Jeremy S Brown
Journal:  Front Immunol       Date:  2019-03-01       Impact factor: 7.561

3.  Human B-1 Cells and B-1 Cell Antibodies Change With Advancing Age.

Authors:  Nely Rodriguez-Zhurbenko; Tam D Quach; Thomas J Hopkins; Thomas L Rothstein; Ana M Hernandez
Journal:  Front Immunol       Date:  2019-03-19       Impact factor: 7.561

Review 4.  Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives.

Authors:  Angelika Wagner; Birgit Weinberger
Journal:  Front Immunol       Date:  2020-04-23       Impact factor: 7.561

Review 5.  Influence of immune aging on vaccine responses.

Authors:  Claire E Gustafson; Chulwoo Kim; Cornelia M Weyand; Jörg J Goronzy
Journal:  J Allergy Clin Immunol       Date:  2020-05       Impact factor: 10.793

6.  A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease.

Authors:  Fabian Uddén; Jonas Ahl; Nils Littorin; Kristoffer Strålin; Simon Athlin; Kristian Riesbeck
Journal:  mSphere       Date:  2020-02-05       Impact factor: 4.389

7.  Upper airways colonisation of Streptococcus pneumoniae in adults aged 60 years and older: A systematic review of prevalence and individual participant data meta-analysis of risk factors.

Authors:  Emma L Smith; India Wheeler; Hugh Adler; Daniela M Ferreira; Raquel Sá-Leão; Osman Abdullahi; Ifedayo Adetifa; Sylvia Becker-Dreps; Susanna Esposito; Helmia Farida; Rama Kandasamy; Grant A Mackenzie; J Pekka Nuorti; Susan Nzenze; Shabir A Madhi; Omar Ortega; Anna Roca; Dodi Safari; Frieder Schaumburg; Effua Usuf; Elisabeth A M Sanders; Lindsay R Grant; Laura L Hammitt; Katherine L O'Brien; Prabhu Gounder; Dana J T Bruden; Michelle C Stanton; Jamie Rylance
Journal:  J Infect       Date:  2020-06-17       Impact factor: 6.072

8.  Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013-2017.

Authors:  Reiko Shimbashi; Motoi Suzuki; Bin Chang; Hiroshi Watanabe; Yoshinari Tanabe; Koji Kuronuma; Kengo Oshima; Takaya Maruyama; Hiroaki Takeda; Kei Kasahara; Jiro Fujita; Junichiro Nishi; Tetsuya Kubota; Keiko Tanaka-Taya; Tamano Matsui; Tomimasa Sunagawa; Kazunori Oishi
Journal:  Emerg Infect Dis       Date:  2020-10       Impact factor: 6.883

Review 9.  Triptych of the Hermit Saints: pneumococcal polysaccharide vaccines for the elderly.

Authors:  Ger T Rijkers; Laura Ie Yousif; Simone Mc Spoorenberg; Frans J van Overveld
Journal:  Risk Manag Healthc Policy       Date:  2018-03-27

Review 10.  Role of Inflammatory Risk Factors in the Pathogenesis of Streptococcus pneumoniae.

Authors:  Ifrah Sohail; Sumit Ghosh; Santhosh Mukundan; Susan Zelewski; M Nadeem Khan
Journal:  Front Immunol       Date:  2018-10-02       Impact factor: 7.561
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