Background: Vitamin D may have anticancer activities. The high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to the cancer health disparities between AAs and European Americans (EAs). Objectives: We compared concentrations of 25(OH)D and vitamin D-binding protein (VDBP) in AA and EA women and investigated determinants of the vitamin D-biomarker concentrations in both populations.Design: We used data and biospecimens from 909 AA and 847 EA healthy control subjects from the Carolina Breast Cancer Study (CBCS) and the Women's Circle of Health Study (WCHS) in the African American Breast Cancer Epidemiology and Risk Consortium. We measured plasma 25(OH)D and VDBP concentrations in all participants and genotyped 67 vitamin D-related genes in AA women only. Results: AA women had lower 25(OH)D concentrations than did EA women (mean ± SD: 14.2 ± 8.1 compared with 21.1 ± 11.5 ng/mL, respectively; P < 0.0001) but similar concentrations of VDBP (mean ± SD: 344 ± 133 compared with 336 ± 124 μg/mL, respectively; P = 0.25). With VDBP and other factors controlled for, the observed racial difference in 25(OH)D concentrations did not diminish. Relations of demographic and lifestyle factors with 25(OH)D were similar between AA and EA women. Although none of the genetic variants that have been identified in previous genome-wide association studies of 25(OH)D concentrations in EAs were significant (P > 0.05) in AAs, AA women who carried the allele of a functional single nucleotide polymorphism rs4988235, which has been previously associated with lactase expression and lactose tolerance, had higher dietary vitamin D intake and higher measured 25(OH)D concentrations.Conclusions: AA women have lower concentrations of total 25(OH)D than EA women do, but both groups have similar VDBP concentrations, suggesting that there are lower concentrations of free 25(OH)D in AAs. Although demographic and lifestyle determinants of 25(OH)D concentrations are similar between the 2 groups, genetic determinants may be ethnicity specific. Larger studies in AAs will be needed to fully elucidate the underlying determinants of low vitamin D concentrations in AA populations.
Background: Vitamin D may have anticancer activities. The high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to the cancer health disparities between AAs and European Americans (EAs). Objectives: We compared concentrations of 25(OH)D and vitamin D-binding protein (VDBP) in AA and EA women and investigated determinants of the vitamin D-biomarker concentrations in both populations.Design: We used data and biospecimens from 909 AA and 847 EA healthy control subjects from the Carolina Breast Cancer Study (CBCS) and the Women's Circle of Health Study (WCHS) in the African American Breast Cancer Epidemiology and Risk Consortium. We measured plasma 25(OH)D and VDBP concentrations in all participants and genotyped 67 vitamin D-related genes in AA women only. Results: AA women had lower 25(OH)D concentrations than did EA women (mean ± SD: 14.2 ± 8.1 compared with 21.1 ± 11.5 ng/mL, respectively; P < 0.0001) but similar concentrations of VDBP (mean ± SD: 344 ± 133 compared with 336 ± 124 μg/mL, respectively; P = 0.25). With VDBP and other factors controlled for, the observed racial difference in 25(OH)D concentrations did not diminish. Relations of demographic and lifestyle factors with 25(OH)D were similar between AA and EA women. Although none of the genetic variants that have been identified in previous genome-wide association studies of 25(OH)D concentrations in EAs were significant (P > 0.05) in AAs, AA women who carried the allele of a functional single nucleotide polymorphism rs4988235, which has been previously associated with lactase expression and lactose tolerance, had higher dietary vitamin D intake and higher measured 25(OH)D concentrations.Conclusions: AA women have lower concentrations of total 25(OH)D than EA women do, but both groups have similar VDBP concentrations, suggesting that there are lower concentrations of free 25(OH)D in AAs. Although demographic and lifestyle determinants of 25(OH)D concentrations are similar between the 2 groups, genetic determinants may be ethnicity specific. Larger studies in AAs will be needed to fully elucidate the underlying determinants of low vitamin D concentrations in AA populations.
Authors: Lisa B Signorello; Scott M Williams; Wei Zheng; Jeffrey R Smith; Jirong Long; Qiuyin Cai; Margaret K Hargreaves; Bruce W Hollis; William J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-07-20 Impact factor: 4.254
Authors: Aravind Subramanian; Pablo Tamayo; Vamsi K Mootha; Sayan Mukherjee; Benjamin L Ebert; Michael A Gillette; Amanda Paulovich; Scott L Pomeroy; Todd R Golub; Eric S Lander; Jill P Mesirov Journal: Proc Natl Acad Sci U S A Date: 2005-09-30 Impact factor: 11.205
Authors: Dezheng Huo; Yonglan Zheng; Temidayo O Ogundiran; Clement Adebamowo; Katherine L Nathanson; Susan M Domchek; Timothy R Rebbeck; Michael S Simon; Esther M John; Anselm Hennis; Barbara Nemesure; Suh-Yuh Wu; M Cristina Leske; Stefan Ambs; Qun Niu; Jing Zhang; Nancy J Cox; Olufunmilayo I Olopade Journal: Carcinogenesis Date: 2012-02-22 Impact factor: 4.944
Authors: Song Yao; Gary Zirpoli; Dana H Bovbjerg; Lina Jandorf; Chi Chen Hong; Hua Zhao; Lara E Sucheston; Li Tang; Michelle Roberts; Gregory Ciupak; Warren Davis; Helena Hwang; Candace S Johnson; Donald L Trump; Susan E McCann; Foluso Ademuyiwa; Karen S Pawlish; Elisa V Bandera; Christine B Ambrosone Journal: Breast Cancer Res Date: 2012-04-04 Impact factor: 6.466
Authors: Christine B Ambrosone; Gregory L Ciupak; Elisa V Bandera; Lina Jandorf; Dana H Bovbjerg; Gary Zirpoli; Karen Pawlish; James Godbold; Helena Furberg; Anne Fatone; Heiddis Valdimarsdottir; Song Yao; Yulin Li; Helena Hwang; Warren Davis; Michelle Roberts; Lara Sucheston; Kitaw Demissie; Kandace L Amend; Paul Tartter; James Reilly; Benjamin W Pace; Thomas Rohan; Joseph Sparano; George Raptis; Maria Castaldi; Alison Estabrook; Sheldon Feldman; Christina Weltz; Margaret Kemeny Journal: J Oncol Date: 2009-10-25 Impact factor: 4.375
Authors: Goncalo R Abecasis; Adam Auton; Lisa D Brooks; Mark A DePristo; Richard M Durbin; Robert E Handsaker; Hyun Min Kang; Gabor T Marth; Gil A McVean Journal: Nature Date: 2012-11-01 Impact factor: 49.962
Authors: Elisa V Bandera; Urmila Chandran; Gary Zirpoli; Susan E McCann; Gregory Ciupak; Christine B Ambrosone Journal: BMC Med Res Methodol Date: 2013-05-31 Impact factor: 4.615
Authors: Song Yao; Chi-Chen Hong; Edward A Ruiz-Narváez; Sharon S Evans; Qianqian Zhu; Beverly A Schaefer; Li Yan; Marie V Coignet; Kathryn L Lunetta; Lara E Sucheston-Campbell; Kelvin Lee; Elisa V Bandera; Melissa A Troester; Lynn Rosenberg; Julie R Palmer; Andrew F Olshan; Christine B Ambrosone Journal: PLoS Genet Date: 2018-06-07 Impact factor: 5.917
Authors: Nazik Elmalaika Husain; Ahmed Abdel Badie Suliman; Ismail Abdelrahman; Shahinaz A Bedri; Rasha M Musa; Hind E Osman; Ayda H Mustafa; Nahla Gafer; Ehab Farah; Ali Abdel Satir; Mohamed H Ahmed; Mugtaba Osman; Atif A Khalil; Abbas Agaimy Journal: J Family Med Prim Care Date: 2019-07
Authors: Barbara B Shih; Mark D Farrar; Marcus S Cooke; Joanne Osman; Abigail K Langton; Richard Kift; Ann R Webb; Jacqueline L Berry; Rachel E B Watson; Andy Vail; Frank R de Gruijl; Lesley E Rhodes Journal: J Invest Dermatol Date: 2018-05-03 Impact factor: 8.551
Authors: Katie M O'Brien; Dale P Sandler; Min Shi; Quaker E Harmon; Jack A Taylor; Clarice R Weinberg Journal: Front Genet Date: 2018-03-01 Impact factor: 4.599
Authors: Michał Ciebiera; Marta Włodarczyk; Magdalena Ciebiera; Kornelia Zaręba; Krzysztof Łukaszuk; Grzegorz Jakiel Journal: Int J Mol Sci Date: 2018-07-14 Impact factor: 5.923