| Literature DB >> 28423947 |
Taowei Yang1,2, Zhiming Rao1,2, Xian Zhang1, Meijuan Xu1, Zhenghong Xu3, Shang-Tian Yang4.
Abstract
Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology.Entities:
Keywords: 2,3-butanediol dehydrogenase; Strain improvement; biotechnological production; cofactor engineering; construction; gene knockout; low-cost substrate; regulation mechanism
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Year: 2017 PMID： 28423947 DOI： 10.1080/07388551.2017.1299680
Source DB: PubMed Journal: Crit Rev Biotechnol ISSN： 0738-8551 Impact factor: 8.429