Literature DB >> 28423332

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming.

Ramon I Klein Geltink1, David O'Sullivan1, Erika L Pearce2.   

Abstract

T cell activation and proliferation critical for protective immunity depend on appropriate rewiring of cellular metabolism. In this issue of Immunity, Mak et al. (2017) show that the antioxidant gluthathione (GSH) controls reactive oxygen species (ROS)-dependent engagement of metabolic signaling pathways that lead to protective T cell responses.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28423332      PMCID： PMC5580393          DOI： 10.1016/j.immuni.2017.03.022

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  10 in total

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Review 6.  Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity.

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  9 in total

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