Literature DB >> 28423084

Immune System Dysfunction in the Elderly.

Eduardo Fuentes1,2, Manuel Fuentes1, Marcelo Alarcón1, Iván Palomo1.   

Abstract

Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.

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Year:  2017        PMID： 28423084     DOI： 10.1590/0001-3765201720160487

Source DB:  PubMed          Journal:  An Acad Bras Cienc        ISSN： 0001-3765            Impact factor:   1.753


  59 in total

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Review 7.  Imaging Approach to Pulmonary Infections in the Immunocompromised Patient.

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