| Literature DB >> 28422419 |
Ji Young Hyun1, Cheol Wan Park1, Yanna Liu1, Daeun Kwon1, Seong-Hyun Park1, Sungjin Park1, Jaeyoung Pai1, Injae Shin1.
Abstract
Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28' and 44', selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28' and 44' selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.Entities:
Keywords: chemical biology; immobilization; lectins; microarrays; selective ligands
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Year: 2017 PMID： 28422419 DOI： 10.1002/cbic.201700091
Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164