S Baumgartner1, B J M van de Heijning2, D Acton2, R P Mensink1. 1. Department of Human Biology and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands. 2. Nutricia Research, Early Life Nutrition, Utrecht, The Netherlands.
Abstract
BACKGROUND/ OBJECTIVES: Fat droplets in human milk (HM) are larger and surrounded by a phospholipid membrane compared with infant milk formulas (IMF). Since the physical structure of fat droplets might affect digestion and postprandial metabolism, an IMF was developed more mimicking HM lipid structure than current IMF. SUBJECTS/ METHODS: A randomised, double-blind, crossover study was performed in 29 fasted healthy men (aged 18-25 years, BMI: 18-25 kg/m2) to compare 5-hour postprandial responses after consumption of an experimental IMF (Concept, Nuturis) with a current IMF (Control). RESULTS:Postprandial triacylglycerol (TAG) concentrations tended to increase faster after intake of Concept IMF (P=0.054), but peaked 3 h after intakes at similar concentrations. ApoB48 increased steadily and peaked 3 h after consumption. Increases in plasma glucose concentrations were comparable, but peak concentrations were reached faster after consumption of Concept IMF (P<0.05). Peak insulin concentrations were higher and reached earlier after intake of Concept IMF, causing a sharper decremental glucose rebound (P<0.05) and an earlier time to nadir in non-esterified fatty acid (NEFA) concentrations (P<0.01). Changes in plasma amino acids (AA), apoB100 and apoA1 were comparable. The incremental or decremental areas under-the-curve did not differ between Concept and Control IMF. Satiety scores and changes in the satiety hormones ghrelin and peptide YY were comparable, while cholecystokinin responses were earlier and higher after consumption of Control IMF (P<0.05). CONCLUSIONS: This proof-of-concept study suggests that fats and carbohydrates from the Concept IMF with larger and phospholipid-coated fat droplets are more rapidly absorbed than those from the current IMF.
RCT Entities:
BACKGROUND/ OBJECTIVES: Fat droplets in human milk (HM) are larger and surrounded by a phospholipid membrane compared with infant milk formulas (IMF). Since the physical structure of fat droplets might affect digestion and postprandial metabolism, an IMF was developed more mimicking HM lipid structure than current IMF. SUBJECTS/ METHODS: A randomised, double-blind, crossover study was performed in 29 fasted healthy men (aged 18-25 years, BMI: 18-25 kg/m2) to compare 5-hour postprandial responses after consumption of an experimental IMF (Concept, Nuturis) with a current IMF (Control). RESULTS: Postprandial triacylglycerol (TAG) concentrations tended to increase faster after intake of Concept IMF (P=0.054), but peaked 3 h after intakes at similar concentrations. ApoB48 increased steadily and peaked 3 h after consumption. Increases in plasma glucose concentrations were comparable, but peak concentrations were reached faster after consumption of Concept IMF (P<0.05). Peak insulin concentrations were higher and reached earlier after intake of Concept IMF, causing a sharper decremental glucose rebound (P<0.05) and an earlier time to nadir in non-esterified fatty acid (NEFA) concentrations (P<0.01). Changes in plasma amino acids (AA), apoB100 and apoA1 were comparable. The incremental or decremental areas under-the-curve did not differ between Concept and Control IMF. Satiety scores and changes in the satiety hormones ghrelin and peptide YY were comparable, while cholecystokinin responses were earlier and higher after consumption of Control IMF (P<0.05). CONCLUSIONS: This proof-of-concept study suggests that fats and carbohydrates from the Concept IMF with larger and phospholipid-coated fat droplets are more rapidly absorbed than those from the current IMF.
Authors: P W Jeroen Maljaars; Robert J P van der Wal; Tom Wiersma; Harry P F Peters; Edward Haddeman; Ad A M Masclee Journal: Clin Nutr Date: 2012-01-02 Impact factor: 7.324
Authors: Andreas Steingoetter; Tijana Radovic; Simon Buetikofer; Jelena Curcic; Dieter Menne; Michael Fried; Werner Schwizer; Tim J Wooster Journal: Am J Clin Nutr Date: 2015-02-25 Impact factor: 7.045
Authors: Evan Abrahamse; Mans Minekus; George A van Aken; Bert van de Heijning; Jan Knol; Nana Bartke; Raish Oozeer; Eline M van der Beek; Thomas Ludwig Journal: Food Dig Date: 2012-11-07
Authors: Laura M Breij; Marieke Abrahamse-Berkeveld; Yvan Vandenplas; Sabine N J Jespers; Amerik C de Mol; Poh Choo Khoo; Masendu Kalenga; Stefaan Peeters; Ron H T van Beek; Obbe F Norbruis; Stefanie Schoen; Dennis Acton; Anita C S Hokken-Koelega Journal: Am J Clin Nutr Date: 2019-03-01 Impact factor: 7.045
Authors: A Smolinska; A Baranska; J W Dallinga; R P Mensink; S Baumgartner; B J M van de Heijning; F J van Schooten Journal: Sci Rep Date: 2019-01-24 Impact factor: 4.379
Authors: Steffen van Heijningen; Giorgio Karapetsas; Eline M van der Beek; Gertjan van Dijk; Lidewij Schipper Journal: Front Neurosci Date: 2022-04-29 Impact factor: 4.677
Authors: Oon Hoe Teoh; Tan Pih Lin; Marieke Abrahamse-Berkeveld; Antoinette Winokan; Yap Seng Chong; Fabian Yap; Maya Marintcheva-Petrova; Eline M van der Beek; Lynette P Shek Journal: Nutrients Date: 2022-02-01 Impact factor: 5.717