Literature DB >> 28421440

Transcriptomic changes in human umbilical cord blood endothelial cells under simulated microgravity.

E G Rudimov1, E N Knjazev1, N A Khaustova1, O V Grigorieva1, L B Buravkova2.   

Abstract

Microarray analysis of cultured endothelial cells was performed 24 h after simulated microgravity. A significant change in the expression of 177 genes that can be classified into several functional clusters was detected. Among the genes with overexpression, clusters of cell response to external stimuli and regulation of cell motility and proliferation can be reliably distinguished. Among down-regulated genes, clusters of transcription factors with the "zinc fingers" domain and factors involved in the regulation of morphogenesis and angiogenesis were distinguished. The overlapping of signaling pathways involved in mechanotransduction and inflammatory changes is discussed.

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Year:  2017        PMID： 28421440     DOI： 10.1134/S160767291701001X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  9 in total

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Authors:  S Muid; G R A Froemming; A M Ali; H Nawawi
Journal:  Malays J Pathol       Date:  2013-12       Impact factor: 0.656

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Authors:  Silvia Versari; Giulia Longinotti; Livia Barenghi; Jeanette Anne Marie Maier; Silvia Bradamante
Journal:  FASEB J       Date:  2013-08-02       Impact factor: 5.191

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Authors:  Illés J Farkas; Adám Szántó-Várnagy; Tamás Korcsmáros
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240
  9 in total

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