Literature DB >> 28421439

Sigma-1 receptor antagonist haloperidol attenuates Ca2+ responses induced by glutoxim and molixan in macrophages.

Z I Krutetskaya1, L S Milenina2, A A Naumova2, S N Butov2, V G Antonov2, A D Nozdrachev2.   

Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca2+-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

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Year:  2017        PMID： 28421439     DOI： 10.1134/S1607672917010227

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  13 in total

1.  The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

Authors:  Tsung-Ping Su; Teruo Hayashi; Tangui Maurice; Shilpa Buch; Arnold E Ruoho
Journal:  Trends Pharmacol Sci       Date:  2010-10-01       Impact factor: 14.819

2.  Chlorpromazine inhibits store-operated calcium entry and subsequent noradrenaline secretion in PC12 cells.

Authors:  S Y Choi; Y H Kim; Y K Lee; K T Kim
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

3.  Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.

Authors:  Hongling Zhang; Javier Cuevas
Journal:  J Neurophysiol       Date:  2002-06       Impact factor: 2.714

4.  A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Authors:  G Grynkiewicz; M Poenie; R Y Tsien
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

5.  Differential inhibition of T-type calcium channels by neuroleptics.

Authors:  Celia M Santi; Francisco S Cayabyab; Kathy G Sutton; John E McRory; Janette Mezeyova; Kevin S Hamming; David Parker; Anthony Stea; Terrance P Snutch
Journal:  J Neurosci       Date:  2002-01-15       Impact factor: 6.167

6.  Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

Authors:  Qiang Xie; Yan Zhang; Changbin Zhai; Joseph A Bonanno
Journal:  J Biol Chem       Date:  2002-02-26       Impact factor: 5.157

7.  [The effect of cyclooxygenase and lipoxygenase inhibitors on Ca(2+)-responses induced by glutoxim and molixan in macrophages].

Authors:  L S Kurilova; Z I Krutetskaia; A A Naumova; S N Butov; N I Krutetskaia; V G Antonov
Journal:  Tsitologiia       Date:  2014

8.  Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.

Authors:  Teruo Hayashi; Tsung-Ping Su
Journal:  Cell       Date:  2007-11-02       Impact factor: 41.582

9.  Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells.

Authors:  Enrique J Cobos; Esperanza del Pozo; José M Baeyens
Journal:  J Neurochem       Date:  2007-04-10       Impact factor: 5.372

10.  Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.

Authors:  Mohamed S Amer; Lynn McKeown; Sarka Tumova; Ruifeng Liu; Victoria A L Seymour; Lesley A Wilson; Jacqueline Naylor; Katriona Greenhalgh; Bing Hou; Yasser Majeed; Paul Turner; Alicia Sedo; David J O'Regan; Jing Li; Robin S Bon; Karen E Porter; David J Beech
Journal:  Br J Pharmacol       Date:  2013-03       Impact factor: 8.739
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  1 in total

1.  Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca2+ Responses in Rat Peritoneal Macrophages.

Authors:  L S Milenina; Z I Krutetskaya; V G Antonov; N I Krutetskaya
Journal:  Cell tissue biol       Date:  2022-05-27
  1 in total

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