Xing Li1,2,3,4, Limin Liao5,6,7,8, Guoqing Chen1,2,3,4, Zhaoxia Wang1,2,3,4, Han Deng1,2,3,4. 1. Rehabilitation School of Capital Medical University, Beijing, China. 2. Department of Urology, China Rehabilitation Research Center, Beijing, China. 3. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China. 4. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China. 5. Rehabilitation School of Capital Medical University, Beijing, China. lmliao@263.net. 6. Department of Urology, China Rehabilitation Research Center, Beijing, China. lmliao@263.net. 7. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China. lmliao@263.net. 8. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China. lmliao@263.net.
Abstract
PURPOSE: Sacral nerve and tibial nerve stimulation have been singly used to treat overactive bladder (OAB). This study evaluated the effects of both combined stimulation on treating bladder overactivity in pigs and explored a novel treatment modality for OAB. METHODS: An implant-driven stimulator of the S3 spinal nerve was implanted in 5 pigs. The contralateral tibial nerve was stimulated by an external stimulator. Multiple cystometrograms were performed to determine the effects of single nerve stimulation and combination sacral nerve stimulation (SNS) and tibial nerve stimulation (TNS) on the micturition reflex by infusing normal saline (NS) or acetic acid (AA). RESULTS: AA-induced bladder overactivity significantly reduced bladder capacity (BC) to 16.3 ± 2.2% of the NS control level (389.4 ± 27.68 ml; P < 0.01). When given a single stimulation, both SNS and TNS significantly increased the BC to 39.2 ± 1.6% and 34.9 ± 5.0% of the NS control level (P < 0.01), respectively. Combined SNS and TNS significantly increased the BC to 50.2 ± 5.2% of the NS control level (P < 0.01) and induced a superior inhibitory effect than SNS or TNS alone (P < 0.05). CONCLUSIONS: Combination SNS and TNS induced a superior inhibitory effect on bladder overactivity in pigs compared to single stimulation and thus could be a novel treatment modality for OAB.
PURPOSE: Sacral nerve and tibial nerve stimulation have been singly used to treat overactive bladder (OAB). This study evaluated the effects of both combined stimulation on treating bladder overactivity in pigs and explored a novel treatment modality for OAB. METHODS: An implant-driven stimulator of the S3 spinal nerve was implanted in 5 pigs. The contralateral tibial nerve was stimulated by an external stimulator. Multiple cystometrograms were performed to determine the effects of single nerve stimulation and combination sacral nerve stimulation (SNS) and tibial nerve stimulation (TNS) on the micturition reflex by infusing normal saline (NS) or acetic acid (AA). RESULTS: AA-induced bladder overactivity significantly reduced bladder capacity (BC) to 16.3 ± 2.2% of the NS control level (389.4 ± 27.68 ml; P < 0.01). When given a single stimulation, both SNS and TNS significantly increased the BC to 39.2 ± 1.6% and 34.9 ± 5.0% of the NS control level (P < 0.01), respectively. Combined SNS and TNS significantly increased the BC to 50.2 ± 5.2% of the NS control level (P < 0.01) and induced a superior inhibitory effect than SNS or TNS alone (P < 0.05). CONCLUSIONS: Combination SNS and TNS induced a superior inhibitory effect on bladder overactivity in pigs compared to single stimulation and thus could be a novel treatment modality for OAB.
Authors: Paul Abrams; Linda Cardozo; Magnus Fall; Derek Griffiths; Peter Rosier; Ulf Ulmsten; Philip van Kerrebroeck; Arne Victor; Alan Wein Journal: Neurourol Urodyn Date: 2002 Impact factor: 2.696
Authors: Werner Schäfer; Paul Abrams; Limin Liao; Anders Mattiasson; Francesco Pesce; Anders Spangberg; Arthur M Sterling; Norman R Zinner; Philip van Kerrebroeck Journal: Neurourol Urodyn Date: 2002 Impact factor: 2.696
Authors: E H Weil; J L Ruiz-Cerdá; P H Eerdmans; R A Janknegt; B L Bemelmans; P E van Kerrebroeck Journal: Eur Urol Date: 2000-02 Impact factor: 20.096