Farah Naja1, Nitin Shivappa2,3,4, Lara Nasreddine1, Samer Kharroubi1, Leila Itani5, Nahla Hwalla1, Abla Mehio Sibai6, James R Hebert2,3,4. 1. a Nutrition and Food Sciences Department, Faculty of Agricultural and Food Sciences , American University of Beirut , Beirut , Lebanon. 2. b Cancer Prevention and Control Program , University of South Carolina , Columbia , SC , USA. 3. c Department of Epidemiology and Biostatistics, Arnold School of Public Health , University of South Carolina , Columbia , SC , USA. 4. d Connecting Health Innovations LLC (CHI) , Columbia , SC , USA. 5. e Department of Nutrition and Dietetics, Faculty of Health Sciences , Beirut Arab University , Beirut , Lebanon. 6. f Department of Epidemiology and Population Health, Faculty of Health Sciences , American University of Beirut , Beirut , Lebanon.
Abstract
The aim of this study was to investigate whether inflammation mediates the previously observed direct association between the western dietary pattern (WDP) and metabolic syndrome (MetS) among Lebanese adults. Sociodemographic, lifestyle, dietary pattern scores, anthropometric and biochemical data of 331 adults were used in this study. Inflammation indicators considered were: serum C-reactive protein (CRP) and the dietary inflammatory index (DII). The scores of the WDP were significantly associated with DII (r = .64) but not with serum CRP. Higher CRP levels increased the odds of MetS and four out of five of its components, while no association was found between the DII and MetS. CONCLUSION: The findings of this study confirmed the association of serum CRP with MetS but did not support mediation effect of inflammation on the association between the WDP and MetS. These findings are important to direct future investigations on diet, inflammation and association with diseases risk.
The aim of this study was to investigate whether inflammation mediates the previously observed direct association between the western dietary pattern (WDP) and metabolic syndrome (MetS) among Lebanese adults. Sociodemographic, lifestyle, dietary pattern scores, anthropometric and biochemical data of 331 adults were used in this study. Inflammation indicators considered were: serum C-reactive protein (CRP) and the dietary inflammatory index (DII). The scores of the WDP were significantly associated with DII (r = .64) but not with serum CRP. Higher CRP levels increased the odds of MetS and four out of five of its components, while no association was found between the DII and MetS. CONCLUSION: The findings of this study confirmed the association of serum CRP with MetS but did not support mediation effect of inflammation on the association between the WDP and MetS. These findings are important to direct future investigations on diet, inflammation and association with diseases risk.