Benjamin J Miller1, Yubo Gao1, Kyle R Duchman1. 1. Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Abstract
BACKGROUND AND OBJECTIVES: There is continuing debate regarding the ideal modality for local control of the primary tumor for patients with Ewing's sarcoma. The primary aim of this study is to investigate the impact of the method of local control on overall survival in patients with Ewing's sarcoma. METHODS: The National Cancer Data Base was used to identify patients <40 years of age with high-grade Ewing's sarcoma of bone. A Kaplan-Meier survival analysis was performed at 2, 5, and 10 years. Factors with a level of significance of P < 0.1 at the 5-year time point were included in a multivariate Cox proportional hazards model. RESULTS: Diminished 5-year survival was noted for patients with metastatic disease, local control with radiation alone, age ≥18 years, tumor size >8 cm, and male sex while controlling for tumor site. Surgery alone was consistently the method of local control that resulted in the highest overall survival. CONCLUSIONS: Surgery alone resulted in the best overall survival for patients with Ewing's sarcoma of bone. The results of this investigation provide support to the approach of surgical resection with negative margins when possible.
BACKGROUND AND OBJECTIVES: There is continuing debate regarding the ideal modality for local control of the primary tumor for patients with Ewing's sarcoma. The primary aim of this study is to investigate the impact of the method of local control on overall survival in patients with Ewing's sarcoma. METHODS: The National Cancer Data Base was used to identify patients <40 years of age with high-grade Ewing's sarcoma of bone. A Kaplan-Meier survival analysis was performed at 2, 5, and 10 years. Factors with a level of significance of P < 0.1 at the 5-year time point were included in a multivariate Cox proportional hazards model. RESULTS: Diminished 5-year survival was noted for patients with metastatic disease, local control with radiation alone, age ≥18 years, tumor size >8 cm, and male sex while controlling for tumor site. Surgery alone was consistently the method of local control that resulted in the highest overall survival. CONCLUSIONS: Surgery alone resulted in the best overall survival for patients with Ewing's sarcoma of bone. The results of this investigation provide support to the approach of surgical resection with negative margins when possible.
Authors: Tyler Abarca; Yubo Gao; Varun Monga; Munir R Tanas; Mohammed M Milhem; Benjamin J Miller Journal: J Surg Oncol Date: 2018-04-06 Impact factor: 3.454
Authors: S E Bosma; C Lancia; A J Rueten-Budde; A Ranft; H Gelderblom; M Fiocco; M A J van de Sande; P D S Dijkstra; U Dirksen Journal: Sci Rep Date: 2019-07-29 Impact factor: 4.379
Authors: Jeremy Whelan; Allan Hackshaw; Anne McTiernan; Robert Grimer; David Spooner; Jessica Bate; Andreas Ranft; Michael Paulussen; Herbert Juergens; Alan Craft; Ian Lewis Journal: Clin Sarcoma Res Date: 2018-03-30