Literature DB >> 2841999

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism.

J D Leander1, R C Rathbun, D M Zimmerman.   

Abstract

Various compounds that have been identified in the literature as binding to the [3H]phencyclidine receptor site and as producing behavioral effects similar to phencyclidine (phencyclidine-like) protected mice from maximal electric shock-induced tonic-extensor seizures. These anticonvulsant effects appear to be due to blockade of the N-methyl-D-aspartic acid receptor, as recently reported for phencyclidine-like compounds. Phencyclidine-like compounds produced their anticonvulsant effects at doses that were also neurologically impairing.

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Year:  1988        PMID： 2841999     DOI： 10.1016/0006-8993(88)90839-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

Review 1.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

2.  Dextrorphan effects on cocaine and brainstem perturbation.

Authors:  M Lundien; O J Andy; R W Rockhold; M Andrews; C Dearman
Journal:  Integr Physiol Behav Sci       Date:  1996 Jul-Sep

3.  Anti-amnesic effect of dimemorfan in mice.

Authors:  Hui-Hung Wang; Jyh-Wei Chien; Yueh-Ching Chou; Jyh-Fei Liao; Chieh-Fu Chen
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

4.  Antagonism of various tonic convulsions in mice by dextrorphan and dizocilpine.

Authors:  N Akaike; N Himori
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-06       Impact factor: 3.000

5.  Drug refractory epilepsy in brain damage: effect of dextromethorphan on EEG in four patients.

Authors:  B Schmitt; R Netzer; S Fanconi; P Baumann; E Boltshauser
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-03       Impact factor: 10.154

6.  Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurones.

Authors:  E J Fletcher; J Church; K Abdel-Hamid; J F MacDonald
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739

7.  CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity.

Authors:  G E Fagg; H R Olpe; M F Pozza; J Baud; M Steinmann; M Schmutz; C Portet; P Baumann; K Thedinga; H Bittiger
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

8.  An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2.

Authors:  H C Akunne; J A Monn; A Thurkauf; A E Jacobson; K C Rice; J T Linders; Q Jiang; F Porreca; R B Rothman
Journal:  Neurochem Res       Date:  1994-04       Impact factor: 3.996

9.  Interaction of sigma and PCP-like drugs on operant behaviors in the rat.

Authors:  T J Hudzik; B L Slifer
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

10.  D-Cycloserine: Agonist turned antagonist.

Authors:  T H Lanthorn
Journal:  Amino Acids       Date:  1994-10       Impact factor: 3.520
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