| Literature DB >> 28419567 |
Michael M Myers1,2,3, Amy J Elliott4,5, Hein J Odendaal6, Larry Burd7, Jyoti Angal4,5, Coen Groenewald6, James David Nugent3, Joel S Yang3, Joseph R Isler2, Kim A Dukes8, Fay Robinson8, William P Fifer1,2,3.
Abstract
AIM: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. <br> METHODS: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. <br> RESULTS: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. <br> CONCLUSION: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.Entities:
Keywords: zzm321990SIDSzzm321990; Autonomic development; Blood pressure; Heart rate; Respiration
Mesh：
Year: 2017 PMID： 28419567 PMCID： PMC5530586 DOI： 10.1111/apa.13873
Source DB: PubMed Journal: Acta Paediatr ISSN： 0803-5253 Impact factor: 2.299