BACKGROUND AND PURPOSE: Intravenous alteplase (rtPA) may be associated with seizures and epileptic activity in the electroencephalogram (EEG). The aim of this work was to compare the frequency of seizures and EEG abnormalities between stroke patients treated and not treated with rtPA. METHODS: This was a prospective study of consecutive acute anterior circulation ischaemic stroke patients, with 1-year follow-up. Patients were previously independent, had an admission National Institute of Health Stroke Scale score ≥4, an acute ischaemic lesion and no previous seizures. They received standardized diagnostic and medical care. A video-EEG was performed in 72 h (first EEG); during admission (daily until day 7 and after that if neurological worsening); at discharge and 1 year after stroke. RESULTS: In all, 151 patients (101 treated with rtPA) were included. The frequency of acute and remote symptomatic seizures was not significantly different between rtPA treated and non-treated patients (P = 0.726 and P = 0.748, respectively). Clinical paroxysmal phenomena during rtPA perfusion were observed in five (5%) patients. In the first EEG, rtPA treated patients more often had background diffuse slowing (43.6% vs. 26.0%, P = 0.036). This difference was no longer observed at discharge (24.0% vs. 19.1%, P = 0.517) nor 1 year after (11.8% vs. 10.0%, P = 0.765). No differences were found in the frequency of epileptiform (P = 0.867) or periodic discharges (P = 0.381). CONCLUSIONS: Intravenous alteplase is not associated with an increased risk of clinical or electroencephalographic epileptic phenomena.
BACKGROUND AND PURPOSE: Intravenous alteplase (rtPA) may be associated with seizures and epileptic activity in the electroencephalogram (EEG). The aim of this work was to compare the frequency of seizures and EEG abnormalities between strokepatients treated and not treated with rtPA. METHODS: This was a prospective study of consecutive acute anterior circulation ischaemic strokepatients, with 1-year follow-up. Patients were previously independent, had an admission National Institute of Health Stroke Scale score ≥4, an acute ischaemic lesion and no previous seizures. They received standardized diagnostic and medical care. A video-EEG was performed in 72 h (first EEG); during admission (daily until day 7 and after that if neurological worsening); at discharge and 1 year after stroke. RESULTS: In all, 151 patients (101 treated with rtPA) were included. The frequency of acute and remote symptomatic seizures was not significantly different between rtPA treated and non-treated patients (P = 0.726 and P = 0.748, respectively). Clinical paroxysmal phenomena during rtPA perfusion were observed in five (5%) patients. In the first EEG, rtPA treated patients more often had background diffuse slowing (43.6% vs. 26.0%, P = 0.036). This difference was no longer observed at discharge (24.0% vs. 19.1%, P = 0.517) nor 1 year after (11.8% vs. 10.0%, P = 0.765). No differences were found in the frequency of epileptiform (P = 0.867) or periodic discharges (P = 0.381). CONCLUSIONS: Intravenous alteplase is not associated with an increased risk of clinical or electroencephalographic epileptic phenomena.
Authors: Carla Bentes; Hugo Martins; Ana Rita Peralta; Carlos Casimiro; Carlos Morgado; Ana Catarina Franco; Ana Catarina Fonseca; Ruth Geraldes; Patrícia Canhão; Teresa Pinho E Melo; Teresa Paiva; José M Ferro Journal: J Neurol Date: 2017-08-14 Impact factor: 4.849
Authors: Lindsey R Kuohn; Alison L Herman; Alexandria L Soto; Stacy C Brown; Emily J Gilmore; Lawrence J Hirsch; Charles C Matouk; Kevin N Sheth; Jennifer A Kim Journal: J Stroke Cerebrovasc Dis Date: 2021-10-21 Impact factor: 2.136
Authors: Carla Bentes; Hugo Martins; Ana Rita Peralta; Carlos Morgado; Carlos Casimiro; Ana Catarina Franco; Ana Catarina Fonseca; Ruth Geraldes; Patrícia Canhão; Teresa Pinho E Melo; Teresa Paiva; José M Ferro Journal: Epilepsia Open Date: 2018-03-07
Authors: Johann Philipp Zöllner; Björn Misselwitz; Thomas Mauroschat; Christian Roth; Helmuth Steinmetz; Felix Rosenow; Adam Strzelczyk Journal: Sci Rep Date: 2020-12-03 Impact factor: 4.379
Authors: Johann Philipp Zöllner; Friedhelm C Schmitt; Felix Rosenow; Konstantin Kohlhase; Alexander Seiler; Adam Strzelczyk; Hermann Stefan Journal: Neurol Res Pract Date: 2021-12-06
Authors: Carla Bentes; Ana Rita Peralta; Hugo Martins; Carlos Casimiro; Carlos Morgado; Ana Catarina Franco; Pedro Viana; Ana Catarina Fonseca; Ruth Geraldes; Patrícia Canhão; Teresa Pinho E Melo; Teresa Paiva; José M Ferro Journal: Epilepsia Open Date: 2017-08-23
Authors: Carolina Ferreira-Atuesta; Nico Döhler; Barbara Erdélyi-Canavese; Ansgar Felbecker; Philip Siebel; Natalie Scherrer; Giulio Bicciato; Juliane Schweizer; Lucia Sinka; Lukas L Imbach; Mira Katan; Laura Abraira; Estevo Santamarina; José Álvarez-Sabín; Michael Winklehner; Tim J von Oertzen; Judith N Wagner; Gian Luigi Gigli; Anna Serafini; Francesco Janes; Giovanni Merlino; Mariarosaria Valente; Giorgia Gregoraci; Julian Conrad; Stefan Evers; Piergiorgio Lochner; Frauke Roell; Francesco Brigo; Carla Bentes; Ana Rita Peralta; Teresa Pinho E Melo; Mark R Keezer; John S Duncan; Josemir W Sander; Barbara Tettenborn; Matthias J Koepp; Marian Galovic Journal: Ann Neurol Date: 2021-09-30 Impact factor: 11.274