| Literature DB >> 28418120 |
Su Yong Shim1, Soo Min Cho1, Anipireddy Venkateswarlu1, Do Hyun Ryu1.
Abstract
A Michael addition initiated cyclopropanation/retro-Claisen rearrangement tandem reaction was developed for the enantioselective synthesis of highly functionalized 2,5-dihydrooxepines. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeds to give good yields and high enantioselectivity.Entities:
Keywords: Lewis acids; enantioselectivity; heterocycles; hydrooxepines; rearrangement reactions
Year: 2017 PMID： 28418120 DOI： 10.1002/anie.201700890
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336