Literature DB >> 28417566

Cannabinoid Type 1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa.

Jaderson V Ferreira1, Gisele A Chaves1, Bianca L B Marino1, Kessia P A Sousa1, Lucilene R Souza1, Maiara F B Brito1, Hueldem R C Teixeira1, Carlos H T P da Silva2, Cleydson B R Santos3, Lorane I S Hage-Melim1.   

Abstract

Cannabis sativa withdrawal syndrome is characterized mainly by psychological symptoms. By using computational tools, the aim of this study was to propose drug candidates for treating withdrawal syndrome based on the natural ligands of the cannabinoid type 1 receptor (CB1). One compound in particular, 2-n-butyl-5-n-pentylbenzene-1,3-diol (ZINC1730183, also known as stemphol), showed positive predictions as a human CB1 ligand and for facile synthetic accessibility. Therefore, ZINC1730183 is a favorable candidate scaffold for further research into pharmacotherapeutic alternatives to treat C. sativa withdrawal syndrome.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Cannabis sativa; computational chemistry; medicinal chemistry; structural similarity; virtual screening

Mesh：

Substances：

Year:  2017        PMID： 28417566     DOI： 10.1002/cmdc.201700129

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  7 in total

1.  Larvicidal activity against Aedes aegypti and molecular docking studies of compounds extracted from the endophytic fungus Aspergillus sp. isolated from Bertholletia excelsa Humn. & Bonpl.

Authors:  Inana F Araújo; Victor Hugo de S Marinho; Iracirema da S Sena; Jhone M Curti; Ryan da S Ramos; Ricardo M A Ferreira; Raimundo N P Souto; Irlon M Ferreira
Journal:  Biotechnol Lett       Date:  2022-02-11       Impact factor: 2.461

2.  Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran.

Authors:  Susy Érika de Lima Barros; Henrique Barros de Lima; Leandra Karoline Alves Gonçalves; Lenir Cabral Correia; Maiara de Fátima de Brito Brito; Mariana Pegrucci Barcelos; Guilherme Martins Silva; Carlos Henrique Tomich de Paula da Silva; Rafael Garrett da Costa; Rodrigo Alves Soares Cruz; José Carlos Tavares Carvalho; Lorane Izabel da Silva Hage-Melim
Journal:  Toxicol Res (Camb)       Date:  2022-05-31       Impact factor: 2.680

3.  Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening.

Authors:  Josiane V Cruz; Moysés F A Neto; Luciane B Silva; Ryan da S Ramos; Josivan da S Costa; Davi S B Brasil; Cleison C Lobato; Glauber V da Costa; José Adolfo H M Bittencourt; Carlos H T P da Silva; Franco H A Leite; Cleydson B R Santos
Journal:  Molecules       Date:  2018-02-18       Impact factor: 4.411

4.  Identification of Potential Inhibitors from Pyriproxyfen with Insecticidal Activity by Virtual Screening.

Authors:  Ryan da Silva Ramos; Josivan da Silva Costa; Rai Campos Silva; Glauber Vilhena da Costa; Alex Bruno Lobato Rodrigues; Érica de Menezes Rabelo; Raimundo Nonato Picanço Souto; Carlton Anthony Taft; Carlos Henrique Tomich de Paula da Silva; Joaquín Maria Campos Rosa; Cleydson Breno Rodrigues Dos Santos; Williams Jorge da Cruz Macêdo
Journal:  Pharmaceuticals (Basel)       Date:  2019-01-25

5.  Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening.

Authors:  Elenilze F B Ferreira; Luciane B Silva; Glauber V Costa; Josivan S Costa; Mayara A T Fujishima; Rozires P Leão; André L S Ferreira; Leonardo B Federico; Carlos H T P Silva; Joaquín M C Rosa; Williams J C Macêdo; Cleydson B R Santos
Journal:  Molecules       Date:  2019-08-14       Impact factor: 4.411

Review 6.  A Guide to Targeting the Endocannabinoid System in Drug Design.

Authors:  Adam Stasiulewicz; Katarzyna Znajdek; Monika Grudzień; Tomasz Pawiński; And Joanna I Sulkowska
Journal:  Int J Mol Sci       Date:  2020-04-16       Impact factor: 5.923

7.  Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches.

Authors:  Pedro H F Araújo; Ryan S Ramos; Jorddy N da Cruz; Sebastião G Silva; Elenilze F B Ferreira; Lúcio R de Lima; Williams J C Macêdo; José M Espejo-Román; Joaquín M Campos; Cleydson B R Santos
Journal:  Molecules       Date:  2020-09-12       Impact factor: 4.411
  7 in total

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