Literature DB >> 28417474

First-Trimester Sonographic Evaluation of Palatine Clefts: A Novel Diagnostic Approach.

Selvaraj Ravi Lakshmy1, Selvaraj Deepa2, Nity Rose1, Senthilkumar Mookan3, Joy Agnees3.   

Abstract

OBJECTIVES: Sonographic evaluation of the palate is a difficult task, and most palatine clefts are diagnosed in the neonatal period because of the limitations of 2-dimensional (2D) sonography. The objective is to describe a sonographic technique based on 2D markers for screening of palatine clefts during the nuchal translucency scan and to assess the ability of 3-dimensional (3D) sonography in imaging the normal and abnormal palate.
METHODS: A total of 2014 women who enrolled for first-trimester screening were included in this prospective study. Screening for palatine clefts was done by 2D evaluation of bony landmarks of the palate, which were the appearance of the palatal line in the sagittal view, retronasal triangle in the coronal view, and alveolar ridge of the maxilla in the axial view followed, by 3D evaluation in suspicious cases. All cases included in the study were followed by second-trimester anomaly scans and evaluated postnatally. Additionally, in 100 consecutive normal cases, 3D evaluation of the palate was done.
RESULTS: Visualization of 2D landmarks could be done in all, and 3D assessment was feasible in 94% of cases. Fourteen cases, of which 5 were unilateral, 4 bilateral, and 2 median cleft lip and palate, 2 median cleft palate, and 1 atypical palatine cleft were identified. There were no false-positives results reported, and 1 case of a bifid uvula was missed.
CONCLUSIONS: The study demonstrates that evaluation of the palate can be done at the 11 to 14 week scan based on 2D markers and can also be assessed with 3D sonography. The inclusion of 2D markers in all 3 planes increases the sensitivity for detection of palatine clefts.
© 2017 by the American Institute of Ultrasound in Medicine.

Entities:  

Keywords:  2- and 3-dimensional sonography; cleft lip; cleft palate; first-trimester screening; obstetric ultrasound; orofacial clefts; prenatal diagnosis

Mesh:

Year:  2017        PMID: 28417474     DOI: 10.7863/ultra.16.05084

Source DB:  PubMed          Journal:  J Ultrasound Med        ISSN: 0278-4297            Impact factor:   2.153


  1 in total

Review 1.  Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis.

Authors:  Hanneke E M van der Hoek-Snieders; Antonius J M L van den Heuvel; Harmieke van Os-Medendorp; Digna M A Kamalski
Journal:  Eur J Pediatr       Date:  2019-12-03       Impact factor: 3.183

  1 in total

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