Alberto Pilotto1, Simone Dini2, Julia Daragjati3, Manuela Miolo4, Monica Maria Mion4, Andrea Fontana5, Mario Lo Storto3, Martina Zaninotto4, Alberto Cella2, Paolo Carraro4, Filomena Addante5, Massimiliano Copetti5, Mario Plebani4. 1. Department of Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, National Relevance & High Specialization Hospital, Mura delle Cappuccine 14, Genova, 16128, Italy. alberto.pilotto@galliera.it. 2. Department of Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, National Relevance & High Specialization Hospital, Mura delle Cappuccine 14, Genova, 16128, Italy. 3. Geriatrics unit, Azienda ULSS 16, Padova, Italy. 4. Department of Laboratory Medicine, Azienda ULSS 16 and Azienda Ospedaliera, Padova, Italy. 5. IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Abstract
BACKGROUND: Several scores and biomarkers, i.e., procalcitonin (PCT), were proposed to stratify the mortality risk in community-acquired pneumonia (CAP). AIM: Evaluating prognostic accuracy of PCT and Multidimensional Prognostic Index (MPI) for 1-month mortality risk in older patients with CAP. METHODS: At hospital admission and at discharge, patients were evaluated by a Comprehensive Geriatric Assessment to calculate MPI. Serum PCT was measured at admission and 1, 3, and 5 days after hospital admission. RESULTS: 49 patients were enrolled. The overall 1-month mortality was 44.5 for 100-persons year. Mortality rates were higher with the increasing of MPI. In survived patients, MPI at discharge showed higher predictive accuracy than MPI at admission. Adding PCT levels to admission MPI prognostic accuracy for 1-month mortality significantly increased. CONCLUSION: In older patients with CAP, MPI significantly predicted 1 month mortality. PCT levels significantly improved the accuracy of MPI at admission in predicting 1-month mortality.
BACKGROUND: Several scores and biomarkers, i.e., procalcitonin (PCT), were proposed to stratify the mortality risk in community-acquired pneumonia (CAP). AIM: Evaluating prognostic accuracy of PCT and Multidimensional Prognostic Index (MPI) for 1-month mortality risk in older patients with CAP. METHODS: At hospital admission and at discharge, patients were evaluated by a Comprehensive Geriatric Assessment to calculate MPI. Serum PCT was measured at admission and 1, 3, and 5 days after hospital admission. RESULTS: 49 patients were enrolled. The overall 1-month mortality was 44.5 for 100-persons year. Mortality rates were higher with the increasing of MPI. In survived patients, MPI at discharge showed higher predictive accuracy than MPI at admission. Adding PCT levels to admission MPI prognostic accuracy for 1-month mortality significantly increased. CONCLUSION: In older patients with CAP, MPI significantly predicted 1 month mortality. PCT levels significantly improved the accuracy of MPI at admission in predicting 1-month mortality.
Entities:
Keywords:
Community-acquired pneumonia; Elderly; Procalcitonin, Multidimensional prognostic index
Authors: Alberto Pilotto; Carlo Custodero; Stefania Maggi; Maria Cristina Polidori; Nicola Veronese; Luigi Ferrucci Journal: Ageing Res Rev Date: 2020-03-21 Impact factor: 10.895
Authors: Alberto Pilotto; Eva Topinkova; Helena Michalkova; Maria Cristina Polidori; Alberto Cella; Alfonso Cruz-Jentoft; Christine A F von Arnim; Margherita Azzini; Heidi Gruner; Alberto Castagna; Giovanni Cenderello; Romina Custureri; Carlo Custodero; Tania Zieschang; Alessandro Padovani; Elisabet Sanchez-Garcia; Nicola Veronese Journal: J Am Med Dir Assoc Date: 2022-07-01 Impact factor: 7.802